Small Cell Lung Cancer

Table I : cell lines with wt p53

Cell line	ATCC	Reference
SBC-3		1006
Lu24		1382
MS-18		1382
NCI-H209	HTB-172	1382
NCI-H128	HTB-120	2249
NCI-H1522	CRL-5874	2249
NCI-H2081	CRL-5920	2249
NCI-H446	HTB-171	2249
NCI-H711	CRL-5836	678
NCI-H748	CRL-5841	678

Table II : cell lines with p53 gene deletion or rearrangement

No data

Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)

Cell line	ATCC	Mutation	reference
NCI-H1694	CRL-5888	c.783-1G>T	2249
NCI-H2227	CRL-5934	c.783-2A>C	678
NCI-H526	CRL-5811	splice intron3	678

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
126	TAC	TGC	Tyr	Cys	SM	ACC-LC-172	17	1976	Single report
249	AGG	AGT	Arg	Ser	SM	ACC-LC-48	389	1976	Single report
110	CGT	del1	Arg	Fs.	SM	ACC-LC-49	3	1976	Single report
152	CCG	ins1	Pro	Fs.	SM	ACC-LC-80	8	1976	Single report
245	GGC	TGC	Gly	Cys	SM	COLO-668	86	2249	Mutation in COSMIC database
306	CGA	TGA	Arg	Stop	SM	COR-L51	160	2249	Mutation in COSMIC database
281	GAC	CAC	Asp	His	SM	COR-L96CAR	41	2249	Mutation in COSMIC database
245	GGC	GTC	Gly	Val	SM	CPC-N	84	2249	Mutation in COSMIC database
155	ACC	CCC	Thr	Pro	SM	DMS-153	20	1953	wt in COSMIC
245	GGC	TGC	Gly	Cys	SM	DMS-273	86	2249	Mutation in COSMIC database
241	TCC	TTC	Ser	Phe	SM	DMS-53	101	2249	Mutation in COSMIC database
278	CCT	del2c	Pro	Fs.	SM	DMS-79	1	2249	Mutation in COSMIC database. del2 and ins 1
237	ATG	ATA	Met	Ile	SM	DMS-92	123	16	Single report
273	CGT	CTT	Arg	Leu	SM	GLC14	147	1386	Single report
282	CGG	TGG	Arg	Trp	SM	GLC28	600	1386	Single report
53	TGG	TGA	Trp	Stop	SM	GLC3	7	1386	Single report
146	TGG	TAG	Trp	Stop	DMU	GLC35	46	1386	Single report
175	CGC	CAC	Arg	His	DMU	GLC35	1187	1386	Single report
158	CGC	CTC	Arg	Leu	SM	GLC36	92	1386	Single report
132	AAG	GAG	Lys	Glu	SM	GLC4	25	1386	Single report
332	ATC	del1c	Ile	Fs.	SM	GLC42	4	1386	Single report
326	GAA	TAA	Glu	Stop	SM	GLC44	9	1386	Single report
218	GTG	GGG	Val	Gly	SM	GLC45	11	1386	Single report
144	CAG	CCG	Gln	Pro	SM	GLC7	10	1386	Single report
280	AGA	GGA	Arg	Gly	SM	GLC8	40	1386	Single report
193	CAT	CTT	His	Leu	SM	HOV	55	1386	Single report
294	GAG	TAG	Glu	Stop	SM	IST-SL2	54	2249	Mutation in COSMIC database
294	GAG	del1a	Glu	Fs.	SM	LB647-SCLC	1	2249	Mutation in COSMIC database
278	CCT	CTT	Pro	Leu	SM	LU-130	84	1382	Single report
278	CCT	CTT	Pro	Leu	SM	LU-134-A	84	364	Single report
244	GGC	TGC	Gly	Cys	SM	LU-135	53	364	Single report
248	CGG	CTG	Arg	Leu	SM	LU-138	124	1382	Single report
157	GTC	TTC	Val	Phe	SM	LU-139	177	364	Single report
342	CGA	del1b	Arg	Fs.	SM	LU-140	1	1382	Single report
179	CAT	TAT	His	Tyr	SM	LU-141	128	1382	Single report
156	CGC	del13c	Arg	Fs.	SM	LU-165	1	2249	Mutation in COSMIC database
244	GGC	AGC	Gly	Ser	SM	MS-1	72	2242	Single report
298	GAG	TAG	Glu	Stop	SM	N230	71	1382	Single report
298	GAG	TAG	Glu	Stop	SM	N231	71	1382	Single report
46	TCC	del1b	Ser	Fs.	DMU	NCI-H1048	1	2249	Controversy with other publications
273	CGT	TGT	Arg	Cys	SM	NCI-H1048	687	22	Controversy with other publications
273	CGT	TGT	Arg	Cys	DMU	NCI-H1048	687	2249	Controversy with other publications
249	AGG	AGT	Arg	Ser	SM	NCI-H1105	389	2249	Mutation in COSMIC database
334	GGG	GTG	Gly	Val	SM	NCI-H1184	3	22	Single report
175	CGC	del1b	Arg	Fs.	SM	NCI-H1417	2	678	wt in COSMIC
179	CAT	CAG	His	Gln	SM	NCI-H1436	14	678	wt in COSMIC
194	CTT	CGT	Leu	Arg	SM	NCI-H1450	66	17	Single report
318	CCA	del19b	Pro	Fs.	SM	NCI-H146	1	2249	Mutation in COSMIC database
68	GAG	TAG	Glu	Stop	SM	NCI-H1514	5	22	Single report
151	CCC	CAC	Pro	His	SM	NCI-H1607	33	22	Single report
248	CGG	CTG	Arg	Leu	SM	NCI-H1618	124	22	wt in COSMIC
266	GGA	GTA	Gly	Val	SM	NCI-H1672	51	22	Single report
241	TCC	TGC	Ser	Cys	SM	NCI-H187	36	1712	Single report
273	CGT	CTT	Arg	Leu	SM	NCI-H1881	147	22	Single report
273	CGT	CTT	Arg	Leu	SM	NCI-H1882	147	678	wt in COSMIC
213	CGA	TGA	Arg	Stop	SM	NCI-H1926	306	22	wt in COSMIC
245	GGC	CGC	Gly	Arg	SM	NCI-H1930	20	2249	Mutation in COSMIC database
147	GTT	GAT	Val	Asp	DMU	NCI-H1963	7	22	wt in COSMIC
214	CAT	CGT	His	Arg	DMU	NCI-H1963	69	22	wt in COSMIC
220	TAT	GAT	Tyr	Asp	SM	NCI-H2029	5	2249	Mutation in COSMIC database
248	CGG	CAG	Arg	Gln	SM	NCI-H211	883	22	Single report
209	AGA	TGA	Arg	Stop	SM	NCI-H2141	14	22	Single report
144	CAG	TAG	Gln	Stop	SM	NCI-H2171	53	2249	Mutation in COSMIC database
157	GTC	TTC	Val	Phe	SM	NCI-H2196	177	2249	Mutation in COSMIC database
134	TTT	TTA	Phe	Leu	SM	NCI-H231	4	9	Single report
65	AGA	TGA	Arg	Stop	SM	NCI-H2330	9	2249	Mutation in COSMIC database
277	TGT	TTT	Cys	Phe	SM	NCI-H250	48	2249	Mutation in COSMIC database
236	TAC	TGC	Tyr	Cys	SM	NCI-H345	75	2249	Mutation in COSMIC database
282	CGG	GGG	Arg	Gly	SM	NCI-H510	48	22	wt in COSMIC
283	CGC	CCC	Arg	Pro	SM	NCI-H64	35	2249	Mutation in COSMIC database
171	GAG	TAG	Glu	Stop	SM	NCI-H69	25	47	Confirmed in three other publications
248	CGG	CAG	Arg	Gln	SM	NCI-H719	883	2249	Mutation in COSMIC database
342	CGA	TGA	Arg	Stop	SM	NCI-H774	74	22	Confirmed in another publication
242	TGC	TCC	Cys	Ser	SM	NCI-H841	19	1382	Single report
242	TGC	TCC	Cys	Ser	SM	NCI-H889	19	17	Confirmed in another publication
298	GAG	TAG	Glu	Stop	SM	NCI-N417	71	106	Single report
298	GAG	TAG	Glu	Stop	SM	RERF-LCMA	71	364	Confirmed in another publication
120	AAG	TAG	Lys	Stop	SM	SBC-1	2	2249	Mutation in COSMIC database
248	CGG	CTG	Arg	Leu	SM	SBC-5	124	364	Confirmed in another publication. wt in COSMIC
278	CCT	CGT	Pro	Arg	SM	SCLC-21H	39	2249	Mutation in COSMIC database
85	CCT	del1	Pro	Fs.	SM	SK-LC-2	1	1976	Single report
259	GAC	GTC	Asp	Val	SM	U-1690	21	2021	Single report
248	CGG	CTG	Arg	Leu	SM	U-1906	124	2021	Single report