Ovarian cancer

Table I : cell lines with wt p53

Cell line	ATCC	Reference
KGN		2249
A2780		2249
RMG-1		2249
CH1		925
LK1		925
LK2		925

Table II : cell lines with p53 gene deletion or rearrangement

No data

Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)

No data

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
99	TCC	del2b	Ser	Fs.	SM	6	1	376	Single report
316	CCC	CCT	Pro	Pro	SM	222	6	798	Single report
273	CGT	CAT	Arg	His	SM	2774	780	798	Single report
172	GTT	TTT	Val	Phe	SM	2780CP	19	963	Single report
193	CAT	CTT	His	Leu	SM	A. P.	55	1011	Single report
172	GTT	TTT	Val	Phe	SM	A2780-CP-20	19	798	Single report
196	CGA	TGA	Arg	Stop	SM	C. P./1	241	1011	Single report
193	CAT	CGT	His	Arg	SM	C. V.	86	1011	Single report
136	CAA	TAA	Gln	Stop	SM	Caov-3	47	144	Single report
147	GTT	GAT	Val	Asp	SM	Caov-4	7	144	Single report
213	CGA	TGA	Arg	Stop	SM	DDL11	306	1011	Single report
124	TGC	CGC	Cys	Arg	SM	EFO-21	4	2249	Mutation in COSMIC database
273	CGT	TGT	Arg	Cys	SM	EFO-27	687	2249	Mutation in COSMIC database
143	GTG	del32	Val	Fs.	SM	EG	1	798	Single report
195	ATC	ACC	Ile	Thr	SM	F. P.	90	1011	Single report
194	CTT	CGT	Leu	Arg	SM	G. C.	66	1011	Single report
306	CGA	TGA	Arg	Stop	SM	G. M.	160	1011	Single report
282	CGG	TGG	Arg	Trp	SM	GBM	600	1011	Single report
126	TAC	TGC	Tyr	Cys	SM	IGROV-1	17	2249	wt in two other publications
270	TTT	TTA	Phe	Leu	DMD	IGROV-1/Pt	7	606	Single report
282	CGG	TGG	Arg	Trp	DMD	IGROV-1/Pt	600	606	Single report
281	GAC	TAC	Asp	Tyr	SM	KURAMOCHI	16	144	Single report
126	TAC	del21a	Tyr	InF	SM	NCI/ADR-RES	6	983	Single report
273	CGT	CAT	Arg	His	SM	OC-314	780	2249	Mutation in COSMIC database
215	AGT	CGT	Ser	Arg	SM	OV 90	4	1165	Single report
126	TAC	TGC	Tyr	Cys	SM	OV1P	17	925	Single report
277	TGT	TTT	Cys	Phe	SM	OVCA 432	48	1011	Single report
248	CGG	CAG	Arg	Gln	SM	OVCAR-3	883	144	Single report
130	CTC	GTC	Leu	Val	SM	OVCAR-4	22	2249	wt in another publication
224	GAG	ins3	Glu	InF	SM	OVCAR-5	1	864	wt in COSMIC
126	TAC	del18	Tyr	InF	SM	OVCAR-8	1	864	Single report
239	AAC	GAC	Asn	Asp	SM	PA-1	53	854	Controversy with other publications. wt in COSMIC
316	CCC	CCT	Pro	Pro	SM	PA-1	6	144	Controversy with other publications. wt in COSMIC
195	ATC	ACC	Ile	Thr	SM	PM1015	90	798	Single report
275	TGT	TAT	Cys	Tyr	SM	R. B.	87	1011	Single report
273	CGT	CAT	Arg	His	SM	S. P.	780	1011	Single report
89	CCC	del1a	Pro	Fs.	SM	SK-OV-3	3	2249	Controversy with other publications
179	CAT	CGT	His	Arg	SM	SK-OV-3	146	1018	Controversy with other publications
262	GGT	GTT	Gly	Val	SM	SW626	14	864	Controversy with other publications
273	CGT	CAT	Arg	His	SM	SW626	780	1011	Controversy with other publications
175	CGC	CAC	Arg	His	SM	TOV 112D	1187	1165	Single report
175	CGC	CAC	Arg	His	SM	TYK-nu	1187	2249	Mutation in COSMIC database