Esophageal cancer

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

Esophageal adenocarcinoma

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
273	CGT	AGT	Arg	Ser	DMU	Bic-1	20	2004	Single report
309	CCC	TCC	Pro	Ser	DMU	Bic-1	6	2004	Single report
277	TGT	TTT	Cys	Phe	SM	Flo-1	48	2004	Single report
310	AAC	ins1a	Asn	Fs.	SM	OE19	1	2249	Mutation in COSMIC database

Esophageal SCC

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
248	CGG	TGG	Arg	Trp	SM	COLO-680N	728	2249	Mutation in COSMIC database
234	TAC	TGC	Tyr	Cys	SM	EC-GI-10	133	2249	Mutation in COSMIC database
245	GGC	GTC	Gly	Val	SM	HCE-4	84	5	wt in COSMIC
278	CCT	TCT	Pro	Ser	SM	HCE-6	87	5	Single report
278	CCT	TCT	Pro	Ser	SM	HCE7	87	1317	Single report
220	TAT	TGT	Tyr	Cys	SM	KYSE- 890	336	634	Single report
337	CGC	TGC	Arg	Cys	SM	KYSE-110	19	634	Single report
193	CAT	CTT	His	Leu	DMU	KYSE-1170	55	634	Single report
255	ATC	GTC	Ile	Val	DMU	KYSE-1170	4	634	Single report
194	CTT	GTT	Leu	Val	SM	KYSE-1240	3	634	Single report
193	CAT	CTT	His	Leu	SM	KYSE-1250	55	634	Single report
342	CGA	del7a	Arg	Fs.	SM	KYSE-1260	1	634	Single report
193	CAT	CGT	His	Arg	SM	KYSE-140	86	634	Single report
248	CGG	CAG	Arg	Gln	SM	KYSE-150	883	2249	Mutation in COSMIC database
266	GGA	CGA	Gly	Arg	SM	KYSE-170	20	634	Single report
195	ATC	ACC	Ile	Thr	SM	KYSE-180	90	2249	Mutation in COSMIC database
203	GTG	CTG	Val	Leu	SM	KYSE-190	2	634	Single report
337	CGC	TGC	Arg	Cys	SM	KYSE-200	19	634	Single report
248	CGG	TGG	Arg	Trp	SM	KYSE-220	728	634	Single report
248	CGG	CAG	Arg	Gln	SM	KYSE-350	883	634	Single report
337	CGC	TGC	Arg	Cys	SM	KYSE-410	19	2249	Mutation in COSMIC database
179	CAT	CGT	His	Arg	SM	KYSE-450	146	634	Controversy with other publications
339	GAG	TAG	Glu	Stop	SM	KYSE-450	12	2249	Controversy with other publications
241	TCC	del32c	Ser	Fs.	SM	KYSE-510	1	634	Controversy with other publications
343	GAG	TAG	Glu	Stop	SM	KYSE-510	5	2249	Controversy with other publications
266	GGA	CGA	Gly	Arg	SM	KYSE-590	20	634	Single report
251	ATC	ins1a	Ile	Fs.	SM	KYSE-70	1	634	Single report
273	CGT	TGT	Arg	Cys	SM	KYSE-850	687	634	Single report
175	CGC	CAC	Arg	His	SM	SK-GT-4	1187	462	Single report
214	CAT	CGT	His	Arg	SM	T.T	69	1006	Single report
272	GTG	ATG	Val	Met	SM	T.Tn	105	1006	Single report
272	GTG	ATG	Val	Met	SM	TE-1	105	1144	wt in COSMIC
242	TGC	TAC	Cys	Tyr	SM	TE-10	58	1144	Single report
110	CGT	CTT	Arg	Leu	SM	TE-11	28	1006	Controversy with other publications. wt in COSMIC
237	ATG	ATT	Met	Ile	SM	TE-11	52	1144	Controversy with other publications. wt in COSMIC
342	CGA	TGA	Arg	Stop	SM	TE-15	74	2249	Mutation in COSMIC database
248	CGG	CAG	Arg	Gln	SM	TE-6	883	1144	Single report
237	ATG	ATT	Met	Ile	SM	TE-8	52	2249	Mutation in COSMIC database
267	CGG	del1b	Arg	Fs.	SM	TE-9	2	1144	wt in COSMIC