Cervical cancer

Table I : cell lines with wt p53

Cell line	ATCC	Reference
HeLa*	CCL-2	1006
ME-180*	HTB-33	1006
SKG-IIIa*		1006
SW756*	CRL-10302	2249
CA-SKI*	CRL-1550	2249
SIHA*	HTB-35	2249
KB*	CCL-17	2249
MS-715*	HTB-34	68
C4II*	CRL-1595	68
SKG-II*

* HPV positive
Table II : cell lines with p53 gene deletion or rearrangement
no data
Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)
no data
Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook
Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;
Table of references (available also in the handbook)

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
109	TTC	TTA	Phe	Leu	SM	C2	1	469	Single report
273	CGT	TGT	Arg	Cys	SM	C33A	687	54	Confirmed in two other publications
245	GGC	GTC	Gly	Val	SM	HT-3	84	54	Confirmed in another publication
175	CGC	CAC	Arg	His	SM	IGR/Cut40	1187	573	Single report
131	AAC	del3a	Asn	InF	SM	SKS	7	1782	Single report