Pancreatic cancer

Table I : cell lines with wt p53

Cell line	ATCC	Reference
PK-45		1556

Table II : cell lines with p53 gene deletion or rearrangement

No data

Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)

No data

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
176	TGC	AGC	Cys	Ser	SM	8902	17	428	Single report
151	CCC	TCC	Pro	Ser	SM	8988S	92	428	Single report
134	TTT	del1a	Phe	Fs.	SM	AsPC-1	4	397	Consensus based on four publications. Controversy with other publications
273	CGT	CAT	Arg	His	SM	ASPC-1	780	132	Controversy with other publications. Excluded from the consensus
197	GTG	TTG	Val	Leu	SM	BI	5	1653	Single report
275	TGT	TAT	Cys	Tyr	SM	BJ	87	1653	Single report
220	TAT	TGT	Tyr	Cys	SM	BxPC-3	336	176	Consensus based on six publications. A single publication decsribes a second mutation (neutral mutation)
159	GCC	GTC	Ala	Val	SM	CAPAN-1	50	177	Confirmed in two other publications. wt in COSMIC
273	CGT	CAT	Arg	His	SM	capan-2	780	132	wt in COSMIC
242	TGC	CGC	Cys	Arg	SM	CFPAC-1	14	397	Single report
175	CGC	CAC	Arg	His	SM	FAMPAC	1187	2116	Single report
272	GTG	TTG	Val	Leu	SM	Ger	39	1653	Single report
262	GGT	GTT	Gly	Val	SM	H-74	14	1689	Single report
151	CCC	TCC	Pro	Ser	SM	HPAF-II	92	177	Confirmed in another publication
266	GGA	GAA	Gly	Glu	SM	HPC-Y19	74	440	Single report
193	CAT	CGT	His	Arg	SM	HPC-Y21	86	440	Single report
152	CCG	del1a	Pro	Fs.	SM	HPC-YO	3	440	Single report
249	AGG	ATG	Arg	Met	SM	Hs 700T	64	132	Confirmed in another publication
181	CGC	CAC	Arg	His	SM	HS766T	34	132	Single report
282	CGG	TGG	Arg	Trp	SM	HuP-T3	600	2249	Mutation in COSMIC database
255	ATC	ACC	Ile	Thr	SM	HuP-T4	19	2249	Mutation in COSMIC database
130	CTC	GTC	Leu	Val	SM	IMIM-PC-1	22	177	Single report
306	CGA	TGA	Arg	Stop	SM	IMIM-PC-2	160	177	Single report
132	AAG	AGG	Lys	Arg	SM	MCC1	51	2000	Single report
273	CGT	TGT	Arg	Cys	SM	MDA-Panc3	687	1653	Single report
248	CGG	TGG	Arg	Trp	SM	MIA PaCa-2	728	177	Confirmed in four other publications
209	AGA	del2b	Arg	Fs.	SM	MZ1-PC	14	2249	Mutation in COSMIC database
282	CGG	TGG	Arg	Trp	SM	MZ-PC-2	600	177	Single report
135	TGC	TGG	Cys	Trp	SM	MZ-PC-4	25	177	Single report
282	CGG	GGG	Arg	Gly	SM	PAN-03-JCK	48	1556	Single report
220	TAT	TGT	Tyr	Cys	SM	Panc 89	336	176	Single report
273	CGT	CAT	Arg	His	SM	Panc-1	780	178	Consensus based on four publications. Controversy with one publication
273	CGT	TGT	Arg	Cys	SM	Panc-1	687	177	Controversy with other publications. Excluded from the cosnensus
255	ATC	AAC	Ile	Asn	SM	PANC-10-05	6	2249	Mutation in COSMIC database
176	TGC	AGC	Cys	Ser	SM	Panc-TU-I	17	176	Confirmed in another publication
175	CGC	CAC	Arg	His	SM	PC	1187	1653	Single report
176	TGC	AGC	Cys	Ser	SM	PC-44	17	428	Single report
237	ATG	ATA	Met	Ile	SM	PCI-55	123	1556	Single report
237	ATG	ATA	Met	Ile	SM	PK-1	123	1556	Single report
167	CAG	TAG	Gln	Stop	SM	PK-8	40	1556	Single report
213	CGA	TGA	Arg	Stop	SM	PK-9	306	1556	Single report
255	ATC	ACC	Ile	Thr	SM	PL 45	19	965	Single report
132	AAG	CAG	Lys	Gln	SM	PSN1	14	38	Single report
280	AGA	AAA	Arg	Lys	SM	PT45	78	178	Single report
175	CGC	CAC	Arg	His	SM	RWP-2	1187	177	Single report
282	CGG	TGG	Arg	Trp	SM	SK-PC-1	600	177	Single report
179	CAT	CGT	His	Arg	SM	SK-PC-3	146	177	Single report
175	CGC	CAC	Arg	His	SM	SNU-213	1187	1491	Single report
238	TGT	TAT	Cys	Tyr	SM	SNU-494	98	1491	Single report
245	GGC	AGC	Gly	Ser	SM	SU86.86	440	397	Confirmed in another publication
273	CGT	CAT	Arg	His	SM	Suit-2	780	1653	Single report
220	TAT	TGT	Tyr	Cys	SM	T3M4	336	1653	Single report
273	CGT	CAT	Arg	His	SM	UK Pan-1	780	659	Single report
179	CAT	CGT	His	Arg	SM	YAPC	146	2249	Mutation in COSMIC database