Head and Neck SCC

Table I : cell lines with wt p53

Cell line	ATCC	Ref.		Cell line	ATCC	Ref.
MO24		2252
PCI-30		2252		UPCI-SCC-154		1544
UM-SCC-17A/B		2252		HOC927		105
UM-SCC-25		2252		BICR-10		208
UM-SCC-47		2252		BICR-18		208
UM-SCC-72		2252		MSK-922		600
UM-SCC-74A		2252		MSK-121		600
UM-SCC-74B		2252		MDA-1986		600
UM-SCC-81A		2252		MDA-886		600
UPCI-SCC-3		1544		584		600
UPCI-SCC-30		1544		185		600
UPCI-SCC-40		1544		1483		600
UPCI-SCC-56		1544		183A		600
UPCI-SCC-81		1544		NHOK		626
UPCI-SCC-104		1544		HOK-16B		626
UPCI-SCC-131		1544		HOK-18A		626
UPCI-SCC-142		1544		HAp-2		626

Table II : cell lines with p53 gene deletion or rearrangement

No data

Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)

Cell line	ATCC	Mutation	reference
HSC-2		Splice intron 6	105
BICR-22		Splice intron 8	208
NU		Splice intron 6	105

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
175	CGC	CAC	Arg	His	SM	Detroit562	1187	2249	Mutation in COSMIC database
281	GAC	CAC	Asp	His	SM	TYS	41	1056	Single report
258	GAA	AAA	Glu	Lys	SM	4197	73	1076	Single report
180	GAG	del1b	Glu	Fs.	SM	A253	1	2249	Mutation in COSMIC database
275	TGT	TGG	Cys	Trp	SM	A30	11	2032	Single report
183	TCA	TAA	Ser	Stop	SM	BB30-HNC	3	2249	Mutation in COSMIC database
146	TGG	TGA	Trp	Stop	SM	BICR-16	51	208	Single report
332	ATC	del99	Ile	InF	SM	BICR-19	1	208	Single report
308	CTG	del19	Leu	Fs.	SM	BICR-22	1	208	Single report
282	CGG	CCG	Arg	Pro	SM	BICR-3	21	208	Single report
173	GTG	del3b	Val	InF	SM	BICR-31	2	208	Single report
126	TAC	del21	Tyr	InF	SM	BICR-56	4	208	Single report
192	CAG	TAG	Gln	Stop	SM	BICR-6	85	208	Single report
151	CCC	CAC	Pro	His	SM	BICR-7	33	208	Single report
248	CGG	TGG	Arg	Trp	SM	Ca9-22	728	105	Single report
193	CAT	CTT	His	Leu	SM	CAL-27	55	1854	Single report
175	CGC	CAC	Arg	His	SM	CAL-33	1187	2249	Mutation in COSMIC database
188	CTG	del12	Leu	InF	SM	DOK	1	418	Single report
213	CGA	TGA	Arg	Stop	SM	EVSCC1	306	153	Single report
248	CGG	CTG	Arg	Leu	SM	FaDu	124	153	Confirmed in two other publications
248	CGG	TGG	Arg	Trp	SM	FS-1	728	2252	Single report
267	CGG	TGG	Arg	Trp	SM	GL	37	1846	Single report
193	CAT	CTT	His	Leu	SM	HN	55	2249	Mutation in COSMIC database
266	GGA	CGA	Gly	Arg	SM	HO-1-N-1	20	2249	Mutation in COSMIC database
285	GAG	AAG	Glu	Lys	SM	HOC313	165	105	Single report
126	TAC	TAG	Tyr	Stop	SM	HOC605	14	105	Single report
281	GAC	GAG	Asp	Glu	SM	HOC719	26	105	Single report
205	TAT	TGT	Tyr	Cys	SM	HOC815	117	105	Single report
305	AAG	ins1a	Lys	Fs.	SM	HSC-3	1	105	Single report
248	CGG	CAG	Arg	Gln	SM	HSC-4	883	105	Single report
237	ATG	ATA	Met	Ile	SM	HSC-5	123	105	Single report
266	GGA	GAA	Gly	Glu	SM	HSQ-89	74	2252	Single report
194	CTT	CGT	Leu	Arg	SM	HU 281	66	202	Single report
298	GAG	TAG	Glu	Stop	SM	JSQ-3	71	160	Single report
52	CAA	ins3a	Gln	InF	SM	KOSC-2	1	2249	Mutation in COSMIC database
248	CGG	TGG	Arg	Trp	SM	KOSC-3	728	598	Single report
176	TGC	TGG	Cys	Trp	SM	KUMA-3	19	2252	Single report
179	CAT	CGT	His	Arg	SM	LB771-HNC	146	2249	Mutation in COSMIC database
258	GAA	GGA	Glu	Gly	SM	MDA-1186	20	600	Single report
280	AGA	CCA	Arg	Pro	DMU	MDA-1386	1	600	Single report
282	CGG	TGG	Arg	Trp	DMU	MDA-1386	600	600	Single report
126	TAC	TGC	Tyr	Cys	SM	MDA-1483	17	2032	Single report
273	CGT	CTT	Arg	Leu	SM	MDA-1586	147	600	Single report
218	GTG	GGG	Val	Gly	DMU	MDA-1686	11	600	Single report
256	ACA	del1c	Thr	Fs.	DMU	MDA-1686	1	600	Single report
151	CCC	TCC	Pro	Ser	SM	MDA-183	92	2032	Single report
151	CCC	TCC	Pro	Ser	SM	MDA-686	92	600	Confirmed in another publication
283	CGC	CCC	Arg	Pro	SM	MKG 7	35	1846	Single report
244	GGC	AGC	Gly	Ser	SM	MSK-QLL1	72	600	Single report
196	CGA	TGA	Arg	Stop	SM	MSK-QLL2	241	600	Single report
220	TAT	CAT	Tyr	His	SM	NA	15	105	Single report
248	CGG	TGG	Arg	Trp	SM	NOS-1	728	1784	wt in COSMIC
132	AAG	GAG	Lys	Glu	SM	OC2	25	1854	Single report
173	GTG	TTG	Val	Leu	SM	OC3	68	2224	Single report
266	GGA	GAA	Gly	Glu	SM	OM1	74	105	Single report
283	CGC	CGG	Arg	Arg	MM	OSC-1	5	1207	Single report
299	CTG	CTA	Leu	Leu	MM	OSC-1	2	1207	Single report
346	GAG	AAG	Glu	Lys	MM	OSC-1	1	1207	Single report
280	AGA	ACA	Arg	Thr	SM	OSC-2	92	1207	Single report
116	TCT	TCC	Ser	Ser	DMU	OSC-3	2	1207	Single report
176	TGC	TTC	Cys	Phe	DMU	OSC-3	191	1207	Single report
174	AGG	AGA	Arg	Arg	SM	OSC-4	7	1207	Single report
150	ACA	GCA	Thr	Ala	DMU	OSC-5	3	1207	Single report
190	CCT	CCC	Pro	Pro	DMU	OSC-5	2	1207	Single report
95	TCT	CCT	Ser	Pro	DMU	OSC-6	1	1207	Single report
126	TAC	TAG	Tyr	Stop	DMU	OSC-6	14	1207	Single report
54	TTC	TAC	Phe	Tyr	SM	OSC-7	2	1207	Single report
193	CAT	TAT	His	Tyr	DMU	OSC-8	41	1207	Single report
256	ACA	ATA	Thr	Ile	DMU	OSC-8	6	1207	Single report
273	CGT	CAT	Arg	His	DMU	OSC-9	780	1207	Single report
309	CCC	ACC	Pro	Thr	DMU	OSC-9	2	1207	Single report
286	GAA	AAA	Glu	Lys	SM	PCI-13	86	2252	Single report
336	GAG	TAG	Glu	Stop	SM	SAS	5	2249	Mutation in COSMIC database
216	GTG	GGG	Val	Gly	SM	SCC-12B	5	208	Single report
258	GAA	AAA	Glu	Lys	SM	SCC-13	73	208	Single report
224	GAG	ins5c	Glu	Fs.	SM	SCC-15	1	626	Single report
209	AGA	del2a	Arg	Fs.	SM	SCC-25	20	208	Confirmed in COSMIC database
175	CGC	CAC	Arg	His	SM	SCC-27	1187	208	Single report
273	CGT	CAT	Arg	His	SM	SCC-35	780	160	Single report
151	CCC	TCC	Pro	Ser	SM	SCC-4	92	208	Confirmed in another publication
258	GAA	AAA	Glu	Lys	SM	SCC-4451	73	1937	Single report
274	GTT	del32c	Val	Fs.	SM	SCC-9	1	2249	Mutation in COSMIC database
249	AGG	AGC	Arg	Ser	SM	SKX	34	1846	Single report
196	CGA	TGA	Arg	Stop	SM	SQ-38	241	160	Single report
271	GAG	del1	Glu	Fs.	SM	SQ9G	2	160	Single report
151	CCC	TCC	Pro	Ser	SM	SSC-4	92	202	Single report
274	GTT	del32	Val	Fs.	SM	SSC-9	1	160	Single report
248	CGG	TGG	Arg	Trp	SM	TSU	728	105	Single report
171	GAG	del46c	Glu	Fs.	SM	TU-139	1	626	Single report
151	CCC	TCC	Pro	Ser	SM	TU-177	92	626	Single report
224	GAG	TAG	Glu	Stop	SM	UD-SCC-3	10	1636	Single report
222	CCG	del13	Pro	Fs.	SM	UD-SCC-4	1	1636	Single report
179	CAT	TAT	His	Tyr	SM	UD-SCC-5	128	1636	Single report
220	TAT	TGT	Tyr	Cys	SM	UD-SCC-6	336	1636	Single report
248	CGG	CTG	Arg	Leu	SM	UD-SCC-7	124	1636	Single report
155	ACC	AAC	Thr	Asn	SM	UD-SCC-8	34	1636	Single report
349	GAA	TAA	Glu	Stop	SM	UMB-SCC-745	7	2245	Single report
270	TTT	del1a	Phe	Fs.	SM	UMB-SCC-864	3	2245	Single report
205	TAT	CAT	Tyr	His	SM	UMB-SCC-969	12	2245	Single report
245	GGC	TGC	Gly	Cys	SM	UM-SCC-10A	86	153	Single report
245	GGC	TGC	Gly	Cys	SM	UM-SCC-10B	86	153	Single report
242	TGC	TCC	Cys	Ser	SM	UM-SCC-11B	19	1636	Single report
104	CAG	TAG	Gln	Stop	SM	UM-SCC-12	18	1983	Single report
163	TAC	TGC	Tyr	Cys	SM	UM-SCC-13	140	1983	Single report
277	TGT	del30	Cys	InF	SM	UM-SCC-14	2	1019	Controversy with other publications
277	TGT	del30	Cys	InF	DMU	UM-SCC-14	2	1636	Controversy with other publications
280	AGA	AGT	Arg	Ser	DMU	UM-SCC-14	14	1636	Controversy with other publications
248	CGG	CTG	Arg	Leu	SM	UM-SCC-16	124	153	Single report
148	GAT	del10	Asp	Fs.	SM	UM-SCC-19	2	153	Single report
71	CCC	del2a	Pro	Fs.	SM	UM-SCC-20	1	1983	Single report
220	TAT	TGT	Tyr	Cys	SM	UM-SCC-22	336	2245	Single report
176	TGC	TTC	Cys	Phe	SM	UM-SCC-23	191	153	Single report
273	CGT	TGT	Arg	Cys	SM	UM-SCC-27	687	2245	Single report
248	CGG	CAG	Arg	Gln	SM	UM-SCC-3	883	2245	Single report
158	CGC	CCC	Arg	Pro	SM	UM-SCC-36	21	1983	Single report
213	CGA	TGA	Arg	Stop	SM	UM-SCC-4	306	2245	Single report
278	CCT	GCT	Pro	Ala	SM	UM-SCC-46	24	1983	Single report
157	GTC	TTC	Val	Phe	SM	UM-SCC-5	177	2248	Single report
273	CGT	CTT	Arg	Leu	SM	UM-SCC-57	147	1983	Single report
242	TGC	TTC	Cys	Phe	SM	UM-SCC-63	88	153	Single report
248	CGG	TGG	Arg	Trp	SM	UM-SCC-68	728	1983	Single report
193	CAT	CGT	His	Arg	SM	UM-SCC-81B	86	1983	Single report
306	CGA	TGA	Arg	Stop	SM	UPCI:SCC-103	160	1544	Single report
155	ACC	CCC	Thr	Pro	SM	UPCI:SCC-105	20	1544	Single report
179	CAT	TAT	His	Tyr	SM	UPCI:SCC-111	128	1544	Single report
248	CGG	CAG	Arg	Gln	SM	UPCI:SCC-114	883	1544	Single report
175	CGC	CAC	Arg	His	SM	UPCI:SCC-116	1187	1544	Single report
273	CGT	CAT	Arg	His	SM	UPCI:SCC-122	780	1544	Single report
151	CCC	CAC	Pro	His	SM	UPCI:SCC-125	33	1544	Single report
224	GAG	TAG	Glu	Stop	SM	UPCI:SCC-136	10	1544	Single report
282	CGG	TGG	Arg	Trp	SM	UPCI:SCC-16	600	1544	Single report
155	ACC	CCC	Thr	Pro	SM	UPCI:SCC-172	20	1544	Single report
294	GAG	TAG	Glu	Stop	SM	UPCI:SCC-182	54	1544	Single report
280	AGA	ACA	Arg	Thr	SM	UPCI:SCC-29B	92	1544	Single report
195	ATC	TTC	Ile	Phe	SM	UPCI:SCC-36	29	1544	Single report
248	CGG	CAG	Arg	Gln	SM	UPCI:SCC-70	883	1544	Single report
179	CAT	AAT	His	Asn	SM	UPCI:SCC-72	23	1544	Single report
177	CCC	CGC	Pro	Arg	SM	UPCI:SCC-99	19	1544	Single report
196	CGA	TGA	Arg	Stop	SM	UT-SCC-1	241	1019	Single report
144	CAG	TAG	Gln	Stop	DMU	UT-SCC-10	53	1019	Single report
306	CGA	TGA	Arg	Stop	DMU	UT-SCC-10	160	1019	Single report
342	CGA	TGA	Arg	Stop	SM	UT-SCC-12	74	2250	Single report
110	CGT	TGT	Arg	Cys	DMU	UT-SCC-16	11	1019	Single report
232	ATC	AAC	Ile	Asn	DMU	UT-SCC-16	13	1019	Single report
285	GAG	AAG	Glu	Lys	SM	UT-SCC-19	165	2250	Single report
275	TGT	TTT	Cys	Phe	SM	UT-SCC-2	47	1019	Single report
248	CGG	TGG	Arg	Trp	SM	UT-SCC-20	728	1019	Single report
238	TGT	TTT	Cys	Phe	SM	UT-SCC-22	42	1636	Single report
282	CGG	CCG	Arg	Pro	SM	UT-SCC-30	21	1019	Single report
282	CGG	TGG	Arg	Trp	SM	UT-SCC-33	600	1636	Single report
248	CGG	del9	Arg	InF	SM	UT-SCC-4	1	2250	Single report
151	CCC	CAT	Pro	His	SM	UT-SCC-5	3	1019	Single report
266	GGA	GAA	Gly	Glu	SM	UT-SCC-7	74	2250	Single report
255	ATC	TTC	Ile	Phe	SM	UT-SCC-8	37	2250	Single report
273	CGT	CTT	Arg	Leu	SM	VU1131	147	1996	Single report
282	CGG	TGG	Arg	Trp	SM	VU1365	600	1996	Single report
236	TAC	TAA	Tyr	Stop	SM	YD-10B	12	2189	Single report
258	GAA	GCA	Glu	Ala	SM	YD-15	3	2189	Single report
273	CGT	CAT	Arg	His	SM	YD-8	780	2189	Single report
279	GGG	GAG	Gly	Glu	SM	ZA	42	105	Single report