Breast carcinoma

Table I : cell lines with wt p53

Cell line	ATCC	Reference
MCF-7	HTB-22	2091
MCF10-2A
DU4475	HTB-123	2091
MDA-MB-175VII	HTB-25	2091
MPE600		2091
SK-BR-7		2091
SUM102PT		2091
UACC-812	CRL-1897	2091
ZR75-1	CRL-1500	2091
ZR75-30	CRL-1504	2091
HBL-100*		2029
MRK-NU-1		1006
YMB-1		1006
YMB-1-E		1006

*Positive for SV40

Table II : cell lines with p53 gene deletion or rearrangement

Cell line	ATCC	Reference
MDA- MB-157	HTB-24

Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)

no data

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
179	CAT	AAT	His	Asn	SM	3522 S2	23	1017	Single report
266	GGA	TGA	Gly	Stop	SM	BRC-230	19	1393	Single report
132	AAG	CAG	Lys	Gln	SM	BT-20	14	24	Confirmed in another publication. wt in COSMIC
285	GAG	AAG	Glu	Lys	SM	BT-474	165	24	Confirmed in three other publications
246	ATG	del1c	Met	Fs.	SM	BT-483	1	2029	Controversy with other publications
246	ATG	ATA	Met	Ile	SM	BT-483	33	2091	Controversy with other publications
249	AGG	AGC	Arg	Ser	SM	BT-549	34	24	Single report
224	GAG	AAG	Glu	Lys	SM	CAL-148	8	2249	Mutation in COSMIC database
132	AAG	GAG	Lys	Glu	SM	CAL-85-1	25	2249	Mutation in COSMIC database
280	AGA	ACA	Arg	Thr	SM	CAMA-1	92	2029	wt in COSMIC
241	TCC	TGC	Ser	Cys	SM	EVSA-T	36	2091	wt in COSMIC
248	CGG	CAG	Arg	Gln	SM	H-31	883	1689	Single report
262	GGT	GTT	Gly	Val	SM	H-71	14	1689	Single report
281	GAC	CAC	Asp	His	SM	HCC1007	41	1396	Single report
281	GAC	TAC	Asp	Tyr	SM	HCC1008	16	2258
248	CGG	CAG	Arg	Gln	SM	HCC1143	883	2249	Mutation in COSMIC database
248	CGG	CAG	Arg	Gln	SM	HCC1143	883	2258
108	GGT	del3b	Gly	InF	SM	HCC1187	1	2258
108	GGT	del3a	Gly	InF	SM	HCC1187	1	2249	Mutation in COSMIC database
175	CGC	CAC	Arg	His	SM	HCC1395	1187	1396	Single report
175	CGC	CAC	Arg	His	SM	HCC1395	1187	2258
74	GCC	del6a	Ala	InF	DMU	HCC1419	1	2249	Mutation in COSMIC database
220	TAT	TGT	Tyr	Cys	DMU	HCC1419	336	2249	Mutation in COSMIC database
294	GAG	TAG	Glu	Stop	SM	HCC1569	54	1396	Single report
256	ACA	ins2	Thr	Fs.	SM	HCC1806	2	1396	Single report
306	CGA	TGA	Arg	Stop	SM	HCC1937	160	1396	Confirmed in another publication
306	CGA	TGA	Arg	Stop	SM	HCC1937	160	2258
163	TAC	TGC	Tyr	Cys	SM	HCC1954	140	2258
163	TAC	TGC	Tyr	Cys	SM	HCC1954	140	2249	Mutation in COSMIC database
248	CGG	TGG	Arg	Trp	SM	HCC2157	728	2249	Mutation in COSMIC database
248	CGG	TGG	Arg	Trp	SM	HCC2157	728	2258
283	CGC	TGC	Arg	Cys	SM	HCC2218	27	1396	Single report
241	TCC	del1b	Ser	Fs.	SM	HCC2713	26	2258
213	CGA	TGA	Arg	Stop	SM	HCC2998	306	2249	Mutation in COSMIC database
273	CGT	CTT	Arg	Leu	SM	HCC38	147	1396	Single report
273	CGT	CTT	Arg	Leu	SM	HCC38	147	2258
248	CGG	CAG	Arg	Gln	SM	HCC70	883	1396	Single report
213	CGA	TGA	Arg	Stop	SM	HDQ-P1	306	1713	Single report
249	AGG	GGG	Arg	Gly	SM	HMT-3909	52	552	Single report
157	GTC	TTC	Val	Phe	SM	Hs 578T	177	76	Confirmed in two other publications
157	GTC	TTC	Val	Phe	SM	HS578T	177	2258
215	AGT	ATT	Ser	Ile	SM	L56BR-X1	25	1968	Single report
244	GGC	AGC	Gly	Ser	SM	MAST	72	1393	Single report
285	GAG	AAG	Glu	Lys	SM	MDA-MB-134-VI	165	2029	wt in COSMIC
261	AGT	del26a	Ser	Fs.	SM	MDA-MB-157	1	2029	wt in COSMIC
280	AGA	AAA	Arg	Lys	SM	MDA-MB-231	78	24	Confirmed in another publication
220	TAT	TGT	Tyr	Cys	SM	MDA-MB-330	336	2091	Single report
166	TCA	TAA	Ser	Stop	SM	MDA-MB-361	19	2029	wt in COSMIC
236	TAC	TGC	Tyr	Cys	SM	MDA-MB-415	75	2091	Single report
266	GGA	GAA	Gly	Glu	SM	MDA-MB-435	74	1018	Single report
204	GAG	ins7c	Glu	Fs.	SM	MDA-MB-436	1	2029	Controversy with other publications
273	CGT	CAT	Arg	His	SM	MDA-MB-436	780	1367	Controversy with other publications
368	CAC	del30	His	InF	SM	MDA-MB-453	1	147	wt in COSMIC
273	CGT	CAT	Arg	His	SM	MDA-MB-468	780	9	Confirmed in another publication
132	AAG	AGG	Lys	Arg	SM	MFM-223	51	2249	Mutation in COSMIC database
234	TAC	TAA	Tyr	Stop	SM	MW1C-6.3	10	147	Single report
244	GGC	AGC	Gly	Ser	SM	OCUB-F	72	2091	Single report
244	GGC	AGC	Gly	Ser	SM	OCUB-M	72	2249	Mutation in COSMIC database
277	TGT	TTT	Cys	Phe	SM	R11T	48	1806	Single report
136	CAA	TAA	Gln	Stop	SM	R18T	47	1806	Single report
273	CGT	TGT	Arg	Cys	SM	R30T	687	1806	Single report
175	CGC	CAC	Arg	His	SM	SK-BR-3	1187	76	Confirmed in another publication. wt in COSMIC
161	GCC	GAC	Ala	Asp	SM	SK-BR-5	19	2091	Single report
135	TGC	TTC	Cys	Phe	SM	SUM1315MO2	52	2091	Single report
237	ATG	ATA	Met	Ile	SM	SUM149PT	123	2091	Single report
158	CGC	ins3a	Arg	InF	SM	SUM159PT	1	2091	Single report
144	CAG	TAG	Gln	Stop	SM	SUM185PE	53	2091	Single report
317	CAG	TAG	Gln	Stop	SM	SUM190PT	25	2091	Single report
265	CTG	CCG	Leu	Pro	SM	SUM225CWN	23	2091	Single report
273	CGT	TGT	Arg	Cys	SM	SUM229PE	687	2091	Single report
213	CGA	TGA	Arg	Stop	SM	SUM52PE	306	2091	Single report
194	CTT	TTT	Leu	Phe	SM	T47D	28	9	Confirmed in another publication
342	CGA	TGA	Arg	Stop	SM	UACC-893	74	2029	Single report