Leukemia / Lymphoma Table I : cell lines with wt p53 Cell line ATCC Origin Ref J-111   AML 1006 IM-9 CCL-159 CML-B 1006 ML-1   CML   KMS-12-BM   Myeloma 1006 KMS-12-PE   Myeloma 1006 RPMI-1788 CCL156 Myeloma 1006 Ly3   Diffuse large cell lymphoma 613 DHL4   Diffuse large cell lymphoma 613 JJN-3   Myeloma 98 XG-3   Myeloma 98 PL-21   Myeloid Leukemia 126 ALL-B   ALL 1303 ALL-G   ALL 1303 ALL-K   ALL 1303 NGR   ALL 1303 SCO-1   ALL 1303 BRE   ALL 1303 HAU   ALL 1303 WMN   Burkitt lymphoma 447 FWL   Lymphoblastoid 447 NL2   Lymphoblastoid 447 AG876   Burkitt lymphoma 447 SHO   Burkitt lymphoma 447 JLP119   Burkitt lymphoma 447 EW36   Burkitt lymphoma 447 Reh CRL-8286 ALL 1627 UoC-B1   ALL 1627 UoC-B3   ALL 1627 UoC-B4   ALL 1627 UoC-B11   ALL 1627 SUP-B7   ALL 1627 SUP-B13   ALL 1627 SUP-B15   ALL 1627 EU-1   ALL 1627 EU-3   ALL 1627 Table II : cell lines with p53 gene deletion or rearrangement Cell line ATCC Origin HL-60 CCL-240 promyelocytic leukemia EU-4   ALL Table III : cell lines with p53 splice mutation (exonic mutations that modify splice are listed in table IV) no data Table IV: cell lines with p53 mutations (missense or frameshift) More information is available in the handbook Pos: Codon position (1 to 393); WT: Normal base sequence of the codon in which the mutation occurred; Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown AA: Wild type amino acid; Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion; Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor; NB: Number of tumors with this particular mutant in the database; Ref: reference number; Comments: information; Table of references (available also in the handbook) Pos. WT Mut       AA Mut Comp Name NB Ref Comments Acute Myelogenous Leukemia 306 CGA TGA Arg Stop SM 2L1 160 2048 from patient RUPN84. Single report 236 TAC CAC Tyr His MM CG2 13 356 Single report 237 ATG GTG Met Val MM CG2 14 356 Single report 248 CGG CAG Arg Gln MM CG2 883 356 Single report 133 ATG AAG Met Lys SM HEL 13 1006 wt in COSMIC 248 CGG TGG Arg Trp SM K051 728 243 Single report 248 CGG TGG Arg Trp SM K052 728 243 Single report 248 CGG CAG Arg Gln SM KASUMI-1 883 2249 Mutation in COSMIC database 272 GTG ATG Val Met SM KMOE-2 105 2249 Mutation in COSMIC database 241 TCC CCC Ser Pro SM ML-1 11 2198 Single report 273 CGT CAT Arg His SM MONOMAC-1 780 2198 Single report 241 TCC del1c Ser Fs. SM NOMO-1 4 2249 Mutation in COSMIC database 172 GTT TTT Val Phe DMU OHN-GM 19 2049 Single report 238 TGT TAT Cys Tyr DMU OHN-GM 98 2049 Single report 195 ATC ACC Ile Thr SM SHI-1 90 2207 Single report 288 AAT TAT Asn Tyr SM YSK-21 5 1710 Single report B-Acute Lymphoblastic Leukemia 109 TTC TCC Phe Ser SM ALL-A 3 1303 Single report 265 CTG CCG Leu Pro SM ALL-C 23 1303 Single report 248 CGG CAG Arg Gln SM ALL-PO 883 2249 Mutation in COSMIC database 109 TTC TCC Phe Ser SM ALL-W 3 1303 Single report 248 CGG CAG Arg Gln SM EU-10 883 1627 Single report 248 CGG CAG Arg Gln SM EU-11 883 1627 Single report 248 CGG CAG Arg Gln SM EU-13 883 1627 Single report 273 CGT CTT Arg Leu SM EU-18 147 1627 Single report 248 CGG CAG Arg Gln SM EU-2 883 617 Single report 273 CGT CTT Arg Leu SM EU-6 147 617 Single report 248 CGG CAG Arg Gln SM EU-7 883 617 Single report 246 ATG ACG Met Thr SM GR-ST 13 2249 Mutation in COSMIC database 124 TGC TGA Cys Stop SM HPB-ALL 1 2198 Single report 273 CGT TGT Arg Cys SM KARPAS-45 687 2249 Mutation in COSMIC database 224 GAG ins5 Glu Fs. SM KG-1 1 126 Single report 225 GTT ATT Val Ile SM KG-1a 4 163 Single report 177 CCC TCC Pro Ser SM KMO-90 19 239 Single report 245 GGC AGC Gly Ser SM KOPM30 440 661 Single report 245 GGC CGC Gly Arg SM KOPN32 20 661 Single report 257 CTG GTG Leu Val SM KOPN35 7 661 Single report 282 CGG ins2b Arg Fs. SM KOPN49 1 661 Single report 209 AGA ins4b Arg Fs. SM KOPN63 1 661 Single report 175 CGC TGC Arg Cys MM SCMC-L9 28 478 Single report 248 CGG CAG Arg Gln MM SCMC-L9 883 478 Single report 358 GAG AAG Glu Lys MM SCMC-L9 1 478 Single report 246 ATG ACG Met Thr SM Tanoue 13 2242 Single report 175 CGC CAC Arg His SM TMBL-1 1187 1967 Single report 220 TAT TGT Tyr Cys SM U-698-M 336 2249 Mutation in COSMIC database B-cell Leukemia 281 GAC GGC Asp Gly SM BALL-1 16 2242 Single report 248 CGG CTG Arg Leu SM HL-60(TB) 124 1018 Single report 132 AAG AGG Lys Arg SM KU812 51 1006 wt in COSMIC 285 GAG AAG Glu Lys SM RPMI-8226 165 1018 Single report 237 ATG ATA Met Ile SM WI-L2-NS 123 637 Controversy with other publications 330 CTT CAT Leu His SM WI-L2-NS 4 769 Controversy with other publications B-cell Lymphoma 280 AGA CGA Arg Arg SM 2 1 1098 Single report 127 TCC TTC Ser Phe SM 3 30 1098 Single report 176 TGC TCC Cys Ser SM 5 13 1098 Single report 248 CGG CAG Arg Gln SM 6 883 1098 Single report 273 CGT TGT Arg Cys SM 8 687 1098 Single report 274 GTT CTT Val Leu SM 9 16 1098 Single report 213 CGA CAA Arg Gln DMD A3/KAW 38 3 Single report 234 TAC CAC Tyr His DMD A3/KAW 25 3 Single report 283 CGC CAC Arg His SM DG-75 19 1143 Single report 216 GTG ATG Val Met DMU HT 74 2249 Mutation in COSMIC database 273 CGT CAT Arg His DMU HT 780 2249 Mutation in COSMIC database 158 CGC CAC Arg His DMU LY1 105 613 Single report 176 TGC GGC Cys Gly DMU LY1 7 613 Single report 238 TGT CGT Cys Arg SM LY17 26 613 Single report 176 TGC TTC Cys Phe SM LY2 191 613 Single report 245 GGC GAC Gly Asp SM LY7 171 613 Single report 282 CGG CCG Arg Pro SM LY8 C3 21 613 Single report B-Lineage Diffuse Large Cell Leukemia 248 CGG CAG Arg Gln SM DB 883 2249 Mutation in COSMIC database 273 CGT TGT Arg Cys SM KARPAS-299 687 2249 Mutation in COSMIC database 319 AAG TAG Lys Stop SM KARPAS-422 5 2249 Mutation in COSMIC database Burkitt lymphoma 273 CGT TGT Arg Cys SM Abana 687 2247 Single report 190 CCT del1 Pro Fs. SM AKATA 1 75 Single report 248 CGG CAG Arg Gln SM AKUA 883 447 Single report 206 TTG del1 Leu Fs. SM AS283A 2 44 Single report 193 CAT CGT His Arg SM BJAB 86 75 Single report 273 CGT TGT Arg Cys SM BL-113 687 44 Single report 246 ATG ACG Met Thr SM BL-30 13 75 Single report 237 ATG ATA Met Ile SM BL-37 123 44 Single report 248 CGG CAG Arg Gln SM BL-41 883 75 Single report 176 TGC TAC Cys Tyr DMU BL-49 88 44 Single report 248 CGG TGG Arg Trp DMU BL-49 728 44 Single report 282 CGG TGG Arg Trp SM BL-60 600 44 Single report 273 CGT TGT Arg Cys SM BL-70 687 2249 Mutation in COSMIC database 213 CGA TGA Arg Stop SM BL-99 306 44 Single report 248 CGG CAG Arg Gln SM CA46 883 447 Single report 175 CGC CAC Arg His SM CW678 1187 44 Single report 213 CGA TGA Arg Stop SM DAUDI 306 44 Controversy with other publications 266 GGA GAA Gly Glu SM DAUDI 74 2249 Controversy with other publications 248 CGG CAG Arg Gln SM DH978 883 1030 Single report 206 TTG del1 Leu Fs. SM EB3 2 44 Single report 152 CCG CTG Pro Leu DMD GA-10 91 1819 Single report 232 ATC AAC Ile Asn DMD GA-10 13 1819 Single report 234 TAC TGC Tyr Cys SM JD38 133 44 Confirmed in another publication 132 AAG CAG Lys Gln SM JIYOYE 14 75 Confirmed in another publication 248 CGG CAG Arg Gln SM KK124 883 1007 Single report 248 CGG CAG Arg Gln SM KK125 883 44 Single report 238 TGT TAT Cys Tyr SM LOUCKES 98 75 Confirmed in another publication 238 TGT TAT Cys Tyr SM MC116 98 44 Confirmed in another publication 248 CGG CAG Arg Gln SM NAMALWA 883 75 Confirmed in three other publications 163 TAC CAC Tyr His DMU P3HR1 26 44 Confirmed in two other publications 287 GAG TAG Glu Stop DMU P3HR1 14 44 Confirmed in two other publications 273 CGT TGT Arg Cys SM PP984 687 44 Single report 213 CGA CAA Arg Gln DMD RAJI 38 161 Confirmed in another publication Some publications described only one of the two mutations 234 TAC CAC Tyr His DMD RAJI 25 161 Confirmed in another publication Some publications described only one of the two mutations 254 ATC GAC Ile Asp SM RAMOS 3 44 Confirmed in three other publications 175 CGC ins3a Arg InF SM SG568 1 447 Single report 158 CGC CAC Arg His SM ST486 105 44 Consensus based on three puublications. Controversy with other publications Second mutation found by COSMIC 158 CGC CAC Arg His DMU ST486 105 2249 Controversy with other publications. Excluded from the consensus 239 AAC GAC Asn Asp DMU ST486 53 2249 Controversy with other publications. Excluded from the consensus Chronic Myelocytic Leukemia 289 CTC CAC Leu His SM CG3 2 356 Single report 136 CAA ins1a Gln Fs. SM K-562 1 269 Confirmed in another publication 301 CCA DEL1 Pro Fs. SM KCL-22 2 150 Single report 248 CGG CAG Arg Gln SM KYO-1 883 150 Single report 319 AAG TAG Lys Stop SM LAMA-84 5 2249 Mutation in COSMIC database Erythroleukemia 274 GTT GAT Val Asp SM OCIM2 8 12 Single report Hodgkin disease 175 CGC CAC Arg His DMD CO 1187 55 Single report 282 CGG TGG Arg Trp DMD CO 600 55 Single report 232 ATC del11c Ile Fs. SM HD-MY-Z 1 2249 Mutation in COSMIC database Lymphoid leukemia 273 CGT TGT Arg Cys SM RPMI-8402 687 163 Single report Mantle Cell Lymphoma 147 GTT GGT Val Gly SM Mino 8 1842 Single report Merkel cell carcinoma 241 TCC TTT Ser Phe DMU MCC13 6 2088 Single report 278 CCT TCT Pro Ser DMU MCC13 87 2088 Single report 272 GTG GAG Val Glu SM MCC14/2 12 2088 Single report Multiple Myeloma 255 ATC del6b Ile InF SM MEF-1 2 1363 Single report Myelodysplastic synd. 248 CGG CAG Arg Gln SM SKM-1 883 1363 Single report Myeloid leukemia 175 CGC CAC Arg His SM KY821 1187 126 wt in COSMIC 251 ATC DEL1B Ile Fs. SM TF-1 5 126 Single report 174 AGG DEL26A Arg Fs. SM THP-1 1 126 Confirmed in another publication 172 GTT DEL46A Val Fs. SM U937 2 126 Single report 261 AGT DEL99A Ser InF SM UT7 1 126 Single report Myeloma 273 CGT CAT Arg His SM ARH-77 780 2249 Mutation in COSMIC database 132 AAG AAC Lys Asn SM EJM 33 98 Single report 143 GTG ATG Val Met SM HD-70 34 1004 Single report 337 CGC CTC Arg Leu SM KMS-12-PE 9 2249 Mutation in COSMIC database 261 AGT ACT Ser Thr SM L-363 1 2249 Mutation in COSMIC database 184 GAT TAT Asp Tyr SM LB 831 5 98 Single report 286 GAA AAA Glu Lys SM LP-1 86 2249 Mutation in COSMIC database 285 GAG AAG Glu Lys SM RPMI-8226 165 98 Single report 161 GCC ACC Ala Thr SM U266 75 98 Single report 126 TAC AAC Tyr Asn SM XG-1 6 98 Single report 176 TGC TAC Cys Tyr SM XG-2 88 98 Single report 181 CGC TGC Arg Cys SM XG-4 28 98 Single report 282 CGG TGG Arg Trp SM XG-5 600 98 Single report NK-Leukemia 248 CGG TGG Arg Trp SM KHYG-1 728 1125 Single report Non-Hodgkin's Lymphomas 237 ATG ATA Met Ile DMD OCI-Ly4 123 517 Single report 248 CGG CAG Arg Gln DMD OCI-Ly4 883 517 Single report 248 CGG CAG Arg Gln SM WSU-NHL 883 2249 Mutation in COSMIC database T-cell Acute Lymphoblastic Leukemia 37 TCC CCC Ser Pro MM CCRF-CEM-VLB100 1 1703 Single report 175 CGC CAC Arg His MM CCRF-CEM-VLB100 1187 1703 Single report 248 CGG CAG Arg Gln MM CCRF-CEM-VLB100 883 1703 Single report 196 CGA TGA Arg Stop DMU J-RT3-T3-5 241 2249 Mutation in COSMIC database 360 GGG del1a Gly Fs. DMU J-RT3-T3-5 2 2249 Mutation in COSMIC database 196 CGA TGA Arg Stop MM JURKAT 241 3 Single report 256 ACA GCA Thr Ala MM JURKAT 9 3 Single report 259 GAC GGC Asp Gly MM JURKAT 6 3 Single report 260 TCC GCC Ser Ala MM JURKAT 4 3 Single report 272 GTG ATG Val Met SM Loucy 105 1510 Single report 273 CGT CAT Arg His SM MOLT-13 780 2249 Mutation in COSMIC database 237 ATG AGG Met Arg DMU MOLT-16 8 3 wt in COSMIC 244 GGC TGC Gly Cys DMU MOLT-16 53 3 wt in COSMIC 111 CTG GTG Leu Val SM MOLT-4 1 2242 Controversy with other publications 248 CGG CAG Arg Gln SM MOLT-4 883 27 Controversy with other publications 306 CGA TGA Arg Stop SM MOLT-4 160 2249 Controversy with other publications 11 GAG CAG Glu Gln MM P12-ICHIKAWA 10 2249 Mutation in COSMIC database 248 CGG CCG Arg Pro MM P12-ICHIKAWA 23 2249 Mutation in COSMIC database 248 CGG CAG Arg Gln MM P12-ICHIKAWA 883 2249 Mutation in COSMIC database 273 CGT TGT Arg Cys SM PF-382 687 2249 Mutation in COSMIC database 248 CGG CAG Arg Gln MM SUP-T1 883 2249 Mutation in COSMIC database 267 CGG CTG Arg Leu MM SUP-T1 1 2249 Mutation in COSMIC database 273 CGT CAT Arg His MM SUP-T1 780 2249 Mutation in COSMIC database T-cell leukemia 278 CCT TCT Pro Ser SM ATL1K 87 82 Single report 175 CGC GGC Arg Gly SM HATL 27 323 Single report 176 TGC TAC Cys Tyr SM MT1 88 82 Single report T-cell Lymphoma 196 CGA TGA Arg Stop SM HUT78 241 3 Single report