Bladder carcinoma Table I : cell lines with wt p53 Cell line ATCC Reference BC16   729 HU456   729 HT1197*   729 KK47   729 RT4   561 PSI*   729 RT112   729 TCCSUP   729 UCRU-BL13     UCRU-BL-28     MGH-U     UM-UC2     UM-UC11     UM-UC6     mdm2 overexpression Table II : cell lines with p53 gene deletion or rearrangement No data Table III : cell lines with p53 splice mutation (exonic mutations that modify splice are listed in table IV) No data Table IV: cell lines with p53 mutations (missense or frameshift) More information is available in the handbook Pos: Codon position (1 to 393); WT: Normal base sequence of the codon in which the mutation occurred; Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown AA: Wild type amino acid; Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion; Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor; NB: Number of tumors with this particular mutant in the database; Ref: reference number; Comments: information; Table of references (available also in the handbook) Pos. WT Mut       AA Mut Comp Name NB Ref Comments 280 AGA ACA Arg Thr SM 5637 92 561 Confirmed in three other publications 248 CGG CAG Arg Gln SM 639-V 883 689 Single report 162 ATC AAC Ile Asn DMU 647-V 4 2249 Mutation in COSMIC database 336 GAG TAG Glu Stop DMU 647-V 5 2249 Mutation in COSMIC database 241 TCC TGC Ser Cys SM BFTC-909 36 564 wt in COSMIC 280 AGA ACA Arg Thr SM BL-17 92 859 Single report 126 TAC TAG Tyr Stop SM BT-1 14 689 Single report 241 TCC TTC Ser Phe SM CUBIII 101 729 Single report 158 CGC CAC Arg His SM DSH1 105 2249 Mutation in COSMIC database 126 TAC TAG Tyr Stop SM EJ 14 689 Controversy with other publications 164 AAG GAG Lys Glu SM EJ 25 729 Controversy with other publications 76 GCA del76 Ala Fs. SM FHS 738B1 1 561 Single report 365 CAC CGC His Arg SM HT-1197 1 561 wt in COSMIC 250 CCC CTC Pro Leu SM HT-1376 53 561 Confirmed in two other publications 261 AGT del137 Ser Fs. DMU J82 1 2249 Controversy with other publications Deletion of exon 8 271 GAG AAG Glu Lys MM J82 38 561 Controversy with other publications undocumented 4th mutation (deletion 210 bp) 271 GAG AAG Glu Lys MM J82 38 729 Controversy with other publications 274 GTT TTT Val Phe MM J82 32 561 Controversy with other publications undocumented 4th mutation (deletion 210 bp) 274 GTT TTT Val Phe MM J82 32 729 Controversy with other publications 320 AAG AAC Lys Asn MM J82 5 561 Controversy with other publications undocumented 4th mutation (deletion 210 bp) 320 AAG AAC Lys Asn DMU J82 5 2249 Controversy with other publications 320 AAG AAC Lys Asn MM J82 5 729 Controversy with other publications 241 TCC TAC Ser Tyr SM LB831-BLC 19 2249 Mutation in COSMIC database 213 CGA TGA Arg Stop SM LD137 306 1163 Single report 219 CCC del1a Pro Fs. SM LD600 10 1163 Single report 36 CCG CCA Pro Pro SM LD605 5 1163 Single report 245 GGC GAC Gly Asp SM LD627 171 1163 Single report 280 AGA AAA Arg Lys SM LD630 78 1163 Single report 248 CGG CAG Arg Gln SM LD660 883 1163 Single report 248 CGG CAG Arg Gln SM LD692 883 1163 Single report 158 CGC CTC Arg Leu SM LD700 92 1163 Single report 183 TCA TGA Ser Stop DMU RT-112 29 2249 Controversy with other publications 248 CGG CAG Arg Gln SM RT-112 883 1733 Controversy with other publications 248 CGG CAG Arg Gln DMU RT-112 883 2249 Controversy with other publications 110 CGT CTT Arg Leu SM SCaBER 28 294 Confirmed in another publication 110 CGT CTT Arg Leu SM SD 28 294 Controversy with other publications 116 TCT TGT Ser Cys SM SD 3 689 Controversy with other publications 273 CGT TGT Arg Cys SM SW1710 687 689 Single report 126 TAC TAG Tyr Stop SM T-24 14 689 Controversy with other publications 126 TAC del3a Tyr InF SM T-24 1 561 Controversy with other publications 349 GAA TAA Glu Stop SM TCCSUP 7 561 Single report 113 TTC TGC Phe Cys SM UM-UC-3 9 294 Confirmed in two other publications 126 TAC TAG Tyr Stop DMU VM-CUB-1 14 2249 Controversy with other publications 175 CGC CAC Arg His SM VM-CUB-1 1187 689 Controversy with other publications 175 CGC CAC Arg His DMU VM-CUB-1 1187 2249 Controversy with other publications 158 CGC CTC Arg Leu DMU VM-CUB-2 92 689 Controversy with other publications 158 CGC CTC Arg Leu SM VM-CUB-2 92 294 Controversy with other publications 163 TAC TGC Tyr Cys DMU VM-CUB-2 140 689 Controversy with other publications 278 CCT CTT Pro Leu SM VM-CUB-3 84 689 Single report