Gastric carcinoma

Table I : cell lines with wt p53

Cell line	ATCC	Reference
SNU-520		747
SNU-719		747
NUGC-4		462
STKM-2		1006
MKN-45		462
MKN-74		462

Table II : cell lines with p53 gene deletion or rearrangement

Cell line	ATCC	Reference
KATO III	HTB-103

Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)

No data

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
248	CGG	TGG	Arg	Trp	SM	20M	728	71	Single report
282	CGG	TGG	Arg	Trp	SM	AKG	600	1393	Single report
307	GCA	del7b	Ala	Fs.	SM	ECC4	1	2249	Mutation in COSMIC database
175	CGC	CAC	Arg	His	SM	G42LATE	1187	1393	Single report
11	GAG	CAG	Glu	Gln	DMU	GCIY	10	2249	Mutation in COSMIC database
179	CAT	CAG	His	Gln	DMU	GCIY	14	2249	Mutation in COSMIC database
104	CAG	TAG	Gln	Stop	SM	GT3TKB	18	2249	Mutation in COSMIC database
145	CTG	CGG	Leu	Arg	SM	H-111	10	1689	Single report
273	CGT	TGT	Arg	Cys	SM	H-162	687	1689	Single report
128	CCT	del37	Pro	Fs.	SM	H-30	2	1689	Single report
272	GTG	ATG	Val	Met	SM	H-55	105	1689	Single report
152	CCG	ins1c	Pro	Fs.	SM	HGC-27	2	2249	Mutation in COSMIC database
245	GGC	AGC	Gly	Ser	SM	HSC-39	440	2087	Single report
193	CAT	CCT	His	Pro	SM	HUG-1N	18	2242	Single report
173	GTG	ATG	Val	Met	SM	JR1	77	94	Single report
173	GTG	GCG	Val	Ala	SM	KWS	20	94	Single report
143	GTG	GCG	Val	Ala	SM	MKN-1	20	71	Confirmed in another publication
251	ATC	CTC	Ile	Leu	SM	MKN-28	5	94	Single report
278	CCT	TCT	Pro	Ser	SM	MKN-7	87	2087	Single report
251	ATC	CTC	Ile	Leu	DMU	MKN-74	5	1006	Controversy with other publications. wt in COSMIC
251	ATC	CTC	Ile	Leu	SM	MKN-74	5	94	Controversy with other publications. wt in COSMIC
271	GAG	GCG	Glu	Ala	DMU	MKN-74	3	1006	Controversy with other publications. wt in COSMIC
248	CGG	CAG	Arg	Gln	SM	NCI-N87	883	46	Single report
220	TAT	TGT	Tyr	Cys	SM	NUGC-3	336	94	Confirmed in another publication
342	CGA	TGA	Arg	Stop	SM	OKAJIMA	74	71	Single report
57	GAC	del17	Asp	Fs.	SM	SK-GT-1	2	462	Single report
175	CGC	CAC	Arg	His	SM	SK-GT-2	1187	462	Single report
281	GAC	GAG	Asp	Glu	SM	SK-GT-5	26	462	Single report
205	TAT	TTT	Tyr	Phe	SM	SNU-16	3	46	Single report
216	GTG	ATG	Val	Met	SM	SNU-216	74	747	Single report
266	GGA	GAA	Gly	Glu	SM	SNU-484	74	747	Single report
143	GTG	del1	Val	Fs.	SM	SNU-55	2	46	Single report
273	CGT	CAT	Arg	His	SM	SNU-601	780	747	Single report
282	CGG	TGG	Arg	Trp	SM	SNU-638	600	747	Single report
215	AGT	AAT	Ser	Asn	SM	SNU-668	15	747	Single report
273	CGT	TGT	Arg	Cys	DMU	TGBC11TKB	687	2249	Mutation in COSMIC database
381	AAA	del1a	Lys	Fs.	DMU	TGBC11TKB	1	2249	Mutation in COSMIC database
173	GTG	ATG	Val	Met	SM	TMK-1	77	71	Confirmed in another publication
175	CGC	CAC	Arg	His	SM	YCC-3	1187	46	Single report