Sunday, 25 June 2017

Solamargine kháng JTC26

Action of solamargine on human lung cancer cells enhancement of the ...

Solamargine kháng JTC26

From Wikipedia, the free encyclopedia
Solamargine
Solamargine.svg
Names
IUPAC name
(3β,22α,25R)-Spirosol-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1→2)-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside
Other names
Solamargin; δ-Solanigrine
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
Properties
C45H73NO15
Molar mass868.07 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Solamargine is a poisonous chemical compound that occurs in plants of the Solanaceae family, such as potatoestomatoes, and eggplants.[1][2] It has been also isolated from Solanum nigrum fungal endophyte Aspergillus flavus[3] It is a glycoalkaloid derived from the steroidal alkaloid solasodine.
Solamargine was one component of the unsuccessful experimental cancer drug candidate Coramsine.

See also[edit]

Cassia tora kháng JTC26

Cassia tora L. (Jue‑ming‑zi) has anticancer activity in TCA8113 cells in ...

Cassia tora kháng JTC26

From Wikipedia, the free encyclopedia
Cassia tora is a dicot legume known as sickle sennasickle podtoracoffee podtovarachakvadthakara in Malayalam and foetid cassia.[1] It is mostly found in South-East Asia and the South West Pacific as an important weed. It is considered a wild weed, wild peanut or pistache that has many healing benefits. The plant is an herbaceous annual foetid herb. The plant can grow 30–90 centimetres (12–35 in) tall and consists of alternative pinnate leaves with leaflets mostly with three opposite pairs that are obovate in shape with a rounded tip. The leaves grow up to 3–4.5 centimeters long. The stems have distinct smelling foliage when young. The flowers are in pairs in axils of leaves with five petals and pale yellow in colour. Cassia tora yellow flowers occur in pairs with stamens of unequal length producing pods that are somewhat flattened or four angled, 10–15 cm long and sickle shaped, hence the common name sickle pod. There are 30–50 seeds within a pod. The seeds, roots and leaves from this plant has been shown to be very beneficial to the modern system of herbal medicines.

History[edit]

Cassia tora is most likely of Indo - Malayan origin. It is found mostly in India. Numerous authors have confused C. tora and C. obtusifolia two species for years.

Geography[edit]

Cassia tora is found in many parts of the world. It grows abundantly in parts of Afghanistan, India, Nigeria, China, Pakistan, Myanmar, Nepal and Bhutan. It is also grown and cultivated areas in the Himalayas at the elevation of 1400 meters in Nepal. It is distributed throughout India, Sri Lanka, West China and the tropics.

Ethnography[edit]

The whole plant as well as specific parts such as roots, leaves and seeds have been widely used and was suggested to combat different diseases afflicting rural and traditional practitioners of Satpura region of Madhya Pradesh, India. Cassia tora is one of the recognized anthraquinone (organic compound) containing plants and has been used in Chinese and Ayurvedic medicine.
Cassia tora

Growing conditions[edit]

Casia tora is very stress tolerant and is an easy plant to grow. In India, it occurs as a wasteland rainy season weed. Its flowering time is favourable after the monsoon rain. C.tora can grow in dry soil throughout tropical parts and high hills of elevation (Himalayas) of up to 1800 meters as well as the plains. It mainly grows during the period of October to February. The seed has vast soil reserves that can remain viable for up to twenty years and can produce up to 1000 emerged plants per square meter following a precise germinating rain. Once the seed has matured, it is gathered and dried in the sun.
growing plant, about two weeks old
old branch with seeds

Pests/diseases[edit]

In Vanuatu, which is an island in the South Pacific, Cassia tora has been known to suffer limited damage by the leaf-eating larvae of Stegasta variana. Stegasta variana is a species of moth called Gelechild moth.

Stress tolerance[edit]

Cassia tora is considered an annual weed and has a high stress tolerance. The main time that it may die off is the dry season of July–October in South Asia.

Uses[edit]

C.tora has many uses. The plant and seeds are edible. The edible part of the plant varies from 30 to 40 percent. Young leaves can be cooked as a vegetable while the roasted seeds are a good substitute for coffee. It is used as a natural pesticide in organic farms and its powder is most commonly used in the pet food industry. Alternatively, it is mixed with guar gum for use in mining and other industrial applications. The seeds and leaves are also used to treat skin disease and its seeds can be utilized as a laxative. This weed could also become a reliable cheap source of nutritious feed for Ctenopharyngodon idella, a fast-growing exotic carp. Cassia tora tea is a herbal, pure, natural and non-polluted green health beverage. In the Republic of Korea, it is believed to rejuvenate human vision. Additionally, the tea has created a new term “coffee-tea”, because of its mysterious but very rich taste and its coffee aroma. It is made from 100 percent Cassia tora, with no artificial colouring and no caffeine, and could be a healthier substitute for coffee and sodas. Since Cassia tora has an external germicide and antiparasitic character, it has been used for treating skin diseases such as leprosy, ringworm, itching and psoriasis and also for snakebites. Other medicinal provisions from plant parts include balm for arthritis using leaves of Cassia tora.
Nutritional Information A natural gelling agent that has industrial and food benefits is made from the seed. The primary chemical constituents of the seed include cinnamaldehyde, gum, tanninsmannitolcoumarins and essential oils (aldehydeseugenol and pinene). The seeds also contain sugars, resins and mucilage, among other elements.

Economics[edit]

The galactomannans (a form of polysaccharide) from Cassia tora (CT- gum), after proper processing and chemical derivatization (converting chemical into a product of a similar structure), could function as an improved and more economical thickener than locust bean gum for textiles, because of the bean gum’s current high price ($18/kg) and limited availability. Most of the CT-gum processing plants in India are located in Gujarat state because of the availability of Cassia tora beans in the neighbouring states, but the widespread use of these beans as vegetables and seeds as cattle feed has been pushing up the raw material cost for the CT-gum industry. The total fixed capacity in the country is 0.2 million tonnes for splits and 59,000 for powder based on Cassia tora seeds. The capacity utilization in the industry has been around 70 percent for the last three years. Apart from domestic consumption, there are now noteworthy exports of cassia powder of the international standard to various countries. This includes the United States of America, Australia, Germany, France, Spain, Denmark, Italy, the Netherlands, Belgium, New Zealand, the United Kingdom, Singapore and Japan. The export value of Cassia tora has been progressively increasing over the last five years. Comprehensive export data disclosed that Japan and the UK receive a regular supply, while the United States market fluctuates. However, the export growth rate of Cassia tora plainly shows the difference between quantity and value, which leads to a low price per unit price.

Social, gender and cultural issues[edit]

Cassia tora is culturally accepted, as it is a natural growing species. The plant is a more holistic use for many ailments and contributes to the nutrition of sustenance families. It is not a laborious species as it is considered as a weed globally, which means it is a very hardy plant species. It can be used in semi-urban areas and in rural areas. One caution when planting in a rural area is to not plant it in a pasture. The effect of ingesting this crop on a daily basis for foraging animals has not been studied.

Constraints for wider use[edit]

An immense reason for why it is not grown more often is because of lack of knowledge people have of the plant. Cassia tora is not well known for many sustenance farmers in the region of where it is optimal to plant. Cassia tora is very affordable. It would be a great benefit to them as said in the economic section that it can be a large production for CT gum. Families of sustenance farmers or urban families can benefit from the medicinal and nutritional uses that it has because they would not have to spend as much money on buying goods such as laxatives, medicinal creams and ointments, coffee, and some vegetables.

Practical information[edit]

Here are directions on how to grow your own Cassia tora plant. Scratch and then pre-soak the seed for 2–3 hours in warm water before sowing it from early spring to early summer in a warm greenhouse or pot in your own home. The seed usually germinates in 1–12 weeks at 23 °C. You can also transplant Cassia tora. Plant them in individual pots once they are large enough to handle and grow them on in the greenhouse or your home. Do not plant them outside until the following spring. Using the Food and Agriculture Organization website is a great tool in finding out more about Cassia tora and its uses, more specifically there is an online brochure called “Country Compass” which lists medicinal herbs for countries across the world.

Solanum kháng JTC26

Patent CA2455425C - Water soluble extract from plant of solanum .

Solanum kháng JTC26

From Wikipedia, the free encyclopedia
Solanum
Starr 020323-0062 Solanum seaforthianum.jpg
Brazilian Nightshade (Solanum seaforthianum)
Scientific classification
Kingdom:Plantae
(unranked):Angiosperms
(unranked):Eudicots
(unranked):Asterids
Order:Solanales
Family:Solanaceae
Subfamily:Solanoideae
Tribe:Solaneae
Genus:Solanum
L.[1]
Subgenera
Bassovia
Leptostemonum
Lyciosolanum
Solanum
(but see text)
Synonyms
Androcera Nutt.
Aquartia Jacq.
Artorhiza Raf.
Bassovia Aubl.
Battata Hill
Bosleria A.Nelson
Ceranthera Raf.
Cliocarpus Miers
Cyphomandra Mart. ex Sendtn.
Diamonon Raf.
Dulcamara Moench
Lycopersicon Mill.
Melongena Mill.
Normania Lowe
Nycterium Vent.
Ovaria Fabr.
Parmentiera Raf. (non DC.: preoccupied)
Petagnia Raf.
Pheliandra Werderm.
Pseudocapsicum Medik.
Scubulus Raf.
Solanastrum Fabr.
Solanocharis Bitter
Solanopsis Bitter
Triguera Cav.
Solanum is a large and diverse genus of flowering plants, which include two food crops of high economic importance, the potato and the tomato. It also contains the nightshades and horse nettles, as well as numerous plants cultivated for their ornamental flowers and fruit.
Solanum species show a wide range of growing habits, such as annual and perennialsvinessubshrubsshrubs, and small trees. Many formerly independent genera like Lycopersicon (the tomatoes) and Cyphomandra are now included in Solanumas subgenera or sections. Thus, the genus today contains roughly 1,500–2,000 species.

Name[edit]

The generic name was first used by Pliny the Elder (23–79) for a plant also known as strychnos, most likely S. nigrum. Its derivation is uncertain, possibly stemming from the Latin word sol, meaning "sun," referring to its status as a plant of the sun. Another possibility is that the root was solare, meaning "to soothe," or solamen, meaning "a comfort," which would refer to the soothing effects of the plant upon ingestion.[2]

Nightshades[edit]

The species most commonly called nightshade in North America and Britain is Solanum dulcamara, also called bittersweet or woody nightshade. Its foliage and egg-shaped red berries are poisonous, the active principle being solanine, which can cause convulsions and death if taken in large doses. The black nightshade (S. nigrum) is also generally considered poisonous, but its fully ripened fruit and foliage are cooked and eaten in some areas. The deadly nightshade (Atropa belladonna) is not in the Solanum genus, but is a member of the wider Solanaceae family.

Food crops[edit]

Most parts of the plants, especially the green parts and unripe fruit, are poisonous to humans (although not necessarily to other animals), but many species in the genus bear some edible parts, such as fruitsleaves, or tubers. Three crops in particular have been bred and harvested for consumption by humans for centuries, and are now cultivated on a global scale:
  • TomatoS. lycopersicum
    • It should be noted that tomato varieties are sometimes bred from both S. lycopersicum and wild tomato species such as S. pimpinellifoliumS. peruvianumS. cheesmaniiS. galapagenseS. chilense, etc. (Such varieties include—among others—Bicentennial, Dwarf Italian, Epoch, Golden Sphere, Hawaii, Ida Red, Indigo Rose,[3] Kauai, Lanai, Marion, Maui, Molokai, Niihau, Oahu, Owyhee, Parma, Payette, Red Lode, Super Star, Surecrop, Tuckers Forcing, V 121, Vantage, Vetomold, and Waltham.)[4]
  • PotatoS. tuberosum
  • Eggplant (aubergine), S. melongena
Other species are significant food crops regionally, such as Ethiopian eggplant and gilo (S. aethiopicum), naranjilla or lulo (S. quitoense), turkey berry (S. torvum), pepino (S. muricatum), Tamarillo, or the "bush tomatoes" (several Australianspecies).

Ornamentals[edit]

The species most widely seen in cultivation as ornamental plants are:-

Medicine[edit]

Poisonings associated with certain species of Solanum are not uncommon and may be fatal. However, several species are locally used in folk medicine, particularly by native peoples who have long employed them.

Ecology[edit]

Solanum species are used as food plants by the larvae of some Lepidoptera species (butterflies and moths) – see list of Lepidoptera that feed on Solanum.

Systematics[edit]

The genus was established by Carl Linnaeus in 1753.[6] Its subdivision has always been problematic, but slowly some sort of consensus is being achieved.
The following list is a provisional lineup of the genus' traditional subdivisions, together with some notable species.[6] Many of the subgenera and sections might not be valid; they are used here provisionally as the phylogeny of this genus is not fully resolved yet and many species have not been reevaluated.
Cladistic analyses of DNA sequence data suggests that the present subdivisions and rankings are largely invalid. Far more subgenera would seem to warrant recognition, with Leptostemonum being the only one that can at present be clearly subdivided into sections. Notably, it includes as a major lineage several members of the traditional sections Cyphomandropsis and the old genus Cyphomandra.[1]

Subgenus Bassovia[edit]

Section Allophylla
Section Cyphomandropsis
Section Pachyphylla

Subgenus Leptostemonum[edit]

Section Acanthophora
Section Androceras: 12 spp.[1]
  • Series Androceras
  • Series Violaceiflorum
  • Series Pacificum
Section Anisantherum
Section Campanulata
Section Crinitum
Section Croatianum
Section Erythrotrichum
Section Graciliflorum[verification needed]
Section Herposolanum
Section Irenosolanum
Section Ischyracanthum
Section Lasiocarpa
Section Melongena
Section Micracantha
Section Monodolichopus
Section Nycterium
Section Oliganthes
Section Persicariae
Section Polytrichum
Section Pugiunculifera
Section Somalanum
Section Torva

Subgenus Lyciosolanum[edit]

Subgenus Solanum sensu stricto[edit]

Currant tomato (S. pimpinellifolium) fruit
Andean black potatoes (S. tuberosum)
Turkey berry (S. torvum) flowers
Section Afrosolanum
Section Anarrhichomenum
Section Archaesolanum
Section Basarthrum
Section Benderianum
Section Brevantherum
Section Dulcamara
Section Herpystichum
Section Holophylla
Section Juglandifolia
Section Lemurisolanum
Section Lycopersicoides
Section Lycopersicon
Section Macronesiotes
Section Normania
Section Petota
Section Pteroidea
Section Quadrangulare
Section Regmandra
Section Solanum

Other notable species[edit]

Forked nightshade (S. furcatum)
Bluewitch nightshade (S. umbelliferum) flowers

Formerly placed here[edit]

Lycianthes rantonnetii and its congeners were often placed in Solanum
Some plants of yet other genera also were placed in Solanum in former times: