Pancreatic cancer

Table I : cell lines with wt p53

Cell line	ATCC	Reference
PK-45		1556

Table II : cell lines with p53 gene deletion or rearrangement

No data

Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)

No data

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
176	TGC	AGC	Cys	Ser	SM	8902	17	428	Single report
151	CCC	TCC	Pro	Ser	SM	8988S	92	428	Single report
134	TTT	del1a	Phe	Fs.	SM	AsPC-1	4	397	Consensus based on four publications. Controversy with other publications
273	CGT	CAT	Arg	His	SM	ASPC-1	780	132	Controversy with other publications. Excluded from the consensus
197	GTG	TTG	Val	Leu	SM	BI	5	1653	Single report
275	TGT	TAT	Cys	Tyr	SM	BJ	87	1653	Single report
220	TAT	TGT	Tyr	Cys	SM	BxPC-3	336	176	Consensus based on six publications. A single publication decsribes a second mutation (neutral mutation)
159	GCC	GTC	Ala	Val	SM	CAPAN-1	50	177	Confirmed in two other publications. wt in COSMIC
273	CGT	CAT	Arg	His	SM	capan-2	780	132	wt in COSMIC
242	TGC	CGC	Cys	Arg	SM	CFPAC-1	14	397	Single report
175	CGC	CAC	Arg	His	SM	FAMPAC	1187	2116	Single report
272	GTG	TTG	Val	Leu	SM	Ger	39	1653	Single report
262	GGT	GTT	Gly	Val	SM	H-74	14	1689	Single report
151	CCC	TCC	Pro	Ser	SM	HPAF-II	92	177	Confirmed in another publication
266	GGA	GAA	Gly	Glu	SM	HPC-Y19	74	440	Single report
193	CAT	CGT	His	Arg	SM	HPC-Y21	86	440	Single report
152	CCG	del1a	Pro	Fs.	SM	HPC-YO	3	440	Single report
249	AGG	ATG	Arg	Met	SM	Hs 700T	64	132	Confirmed in another publication
181	CGC	CAC	Arg	His	SM	HS766T	34	132	Single report
282	CGG	TGG	Arg	Trp	SM	HuP-T3	600	2249	Mutation in COSMIC database
255	ATC	ACC	Ile	Thr	SM	HuP-T4	19	2249	Mutation in COSMIC database
130	CTC	GTC	Leu	Val	SM	IMIM-PC-1	22	177	Single report
306	CGA	TGA	Arg	Stop	SM	IMIM-PC-2	160	177	Single report
132	AAG	AGG	Lys	Arg	SM	MCC1	51	2000	Single report
273	CGT	TGT	Arg	Cys	SM	MDA-Panc3	687	1653	Single report
248	CGG	TGG	Arg	Trp	SM	MIA PaCa-2	728	177	Confirmed in four other publications
209	AGA	del2b	Arg	Fs.	SM	MZ1-PC	14	2249	Mutation in COSMIC database
282	CGG	TGG	Arg	Trp	SM	MZ-PC-2	600	177	Single report
135	TGC	TGG	Cys	Trp	SM	MZ-PC-4	25	177	Single report
282	CGG	GGG	Arg	Gly	SM	PAN-03-JCK	48	1556	Single report
220	TAT	TGT	Tyr	Cys	SM	Panc 89	336	176	Single report
273	CGT	CAT	Arg	His	SM	Panc-1	780	178	Consensus based on four publications. Controversy with one publication
273	CGT	TGT	Arg	Cys	SM	Panc-1	687	177	Controversy with other publications. Excluded from the cosnensus
255	ATC	AAC	Ile	Asn	SM	PANC-10-05	6	2249	Mutation in COSMIC database
176	TGC	AGC	Cys	Ser	SM	Panc-TU-I	17	176	Confirmed in another publication
175	CGC	CAC	Arg	His	SM	PC	1187	1653	Single report
176	TGC	AGC	Cys	Ser	SM	PC-44	17	428	Single report
237	ATG	ATA	Met	Ile	SM	PCI-55	123	1556	Single report
237	ATG	ATA	Met	Ile	SM	PK-1	123	1556	Single report
167	CAG	TAG	Gln	Stop	SM	PK-8	40	1556	Single report
213	CGA	TGA	Arg	Stop	SM	PK-9	306	1556	Single report
255	ATC	ACC	Ile	Thr	SM	PL 45	19	965	Single report
132	AAG	CAG	Lys	Gln	SM	PSN1	14	38	Single report
280	AGA	AAA	Arg	Lys	SM	PT45	78	178	Single report
175	CGC	CAC	Arg	His	SM	RWP-2	1187	177	Single report
282	CGG	TGG	Arg	Trp	SM	SK-PC-1	600	177	Single report
179	CAT	CGT	His	Arg	SM	SK-PC-3	146	177	Single report
175	CGC	CAC	Arg	His	SM	SNU-213	1187	1491	Single report
238	TGT	TAT	Cys	Tyr	SM	SNU-494	98	1491	Single report
245	GGC	AGC	Gly	Ser	SM	SU86.86	440	397	Confirmed in another publication
273	CGT	CAT	Arg	His	SM	Suit-2	780	1653	Single report
220	TAT	TGT	Tyr	Cys	SM	T3M4	336	1653	Single report
273	CGT	CAT	Arg	His	SM	UK Pan-1	780	659	Single report
179	CAT	CGT	His	Arg	SM	YAPC	146	2249	Mutation in COSMIC database

Ovarian cancer

Table I : cell lines with wt p53

Cell line	ATCC	Reference
KGN		2249
A2780		2249
RMG-1		2249
CH1		925
LK1		925
LK2		925

Table II : cell lines with p53 gene deletion or rearrangement

No data

Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)

No data

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
99	TCC	del2b	Ser	Fs.	SM	6	1	376	Single report
316	CCC	CCT	Pro	Pro	SM	222	6	798	Single report
273	CGT	CAT	Arg	His	SM	2774	780	798	Single report
172	GTT	TTT	Val	Phe	SM	2780CP	19	963	Single report
193	CAT	CTT	His	Leu	SM	A. P.	55	1011	Single report
172	GTT	TTT	Val	Phe	SM	A2780-CP-20	19	798	Single report
196	CGA	TGA	Arg	Stop	SM	C. P./1	241	1011	Single report
193	CAT	CGT	His	Arg	SM	C. V.	86	1011	Single report
136	CAA	TAA	Gln	Stop	SM	Caov-3	47	144	Single report
147	GTT	GAT	Val	Asp	SM	Caov-4	7	144	Single report
213	CGA	TGA	Arg	Stop	SM	DDL11	306	1011	Single report
124	TGC	CGC	Cys	Arg	SM	EFO-21	4	2249	Mutation in COSMIC database
273	CGT	TGT	Arg	Cys	SM	EFO-27	687	2249	Mutation in COSMIC database
143	GTG	del32	Val	Fs.	SM	EG	1	798	Single report
195	ATC	ACC	Ile	Thr	SM	F. P.	90	1011	Single report
194	CTT	CGT	Leu	Arg	SM	G. C.	66	1011	Single report
306	CGA	TGA	Arg	Stop	SM	G. M.	160	1011	Single report
282	CGG	TGG	Arg	Trp	SM	GBM	600	1011	Single report
126	TAC	TGC	Tyr	Cys	SM	IGROV-1	17	2249	wt in two other publications
270	TTT	TTA	Phe	Leu	DMD	IGROV-1/Pt	7	606	Single report
282	CGG	TGG	Arg	Trp	DMD	IGROV-1/Pt	600	606	Single report
281	GAC	TAC	Asp	Tyr	SM	KURAMOCHI	16	144	Single report
126	TAC	del21a	Tyr	InF	SM	NCI/ADR-RES	6	983	Single report
273	CGT	CAT	Arg	His	SM	OC-314	780	2249	Mutation in COSMIC database
215	AGT	CGT	Ser	Arg	SM	OV 90	4	1165	Single report
126	TAC	TGC	Tyr	Cys	SM	OV1P	17	925	Single report
277	TGT	TTT	Cys	Phe	SM	OVCA 432	48	1011	Single report
248	CGG	CAG	Arg	Gln	SM	OVCAR-3	883	144	Single report
130	CTC	GTC	Leu	Val	SM	OVCAR-4	22	2249	wt in another publication
224	GAG	ins3	Glu	InF	SM	OVCAR-5	1	864	wt in COSMIC
126	TAC	del18	Tyr	InF	SM	OVCAR-8	1	864	Single report
239	AAC	GAC	Asn	Asp	SM	PA-1	53	854	Controversy with other publications. wt in COSMIC
316	CCC	CCT	Pro	Pro	SM	PA-1	6	144	Controversy with other publications. wt in COSMIC
195	ATC	ACC	Ile	Thr	SM	PM1015	90	798	Single report
275	TGT	TAT	Cys	Tyr	SM	R. B.	87	1011	Single report
273	CGT	CAT	Arg	His	SM	S. P.	780	1011	Single report
89	CCC	del1a	Pro	Fs.	SM	SK-OV-3	3	2249	Controversy with other publications
179	CAT	CGT	His	Arg	SM	SK-OV-3	146	1018	Controversy with other publications
262	GGT	GTT	Gly	Val	SM	SW626	14	864	Controversy with other publications
273	CGT	CAT	Arg	His	SM	SW626	780	1011	Controversy with other publications
175	CGC	CAC	Arg	His	SM	TOV 112D	1187	1165	Single report
175	CGC	CAC	Arg	His	SM	TYK-nu	1187	2249	Mutation in COSMIC database

Non Small Cell Lung Cancer

Table I : cell lines with wt p53

Cell line	ATCC	Ref.	essssssss	Cell line	ATCC	Ref.
A-549	CCL-185	1006		NCI-H1944	CRL-5907	678
LU99		1006		NCI-H2023	CRL-5912	678
LU99A		1006		NCI-H2030	CRL-5914	678
LU99B		1006		NCI-H2077	CRL-5919	678
A427	HTB-53	1382		NCI-H2126	CRL-5925	678
Ma-12		1382		NCI-H2347	CRL-5942	678
Ma-17		1382		NCI-H1395	CRL-5868	2249
Ma-26		1382		NCI-H1563	CRL-5875	2249
NCI-H460	HTB-177	678		NCI-H1650	CRL-5883	678
NCI-H726		678		NCI-H1666	CRL-5885	678
NCI-H838	CRL-5844	678		NCI-H1975	CRL-5908	2249
NCI-H1385	CRL-5867	678		NCI-H2170	CRL-5928	2249
NCI-H1568	CRL-5876	678		NCI-H2228	CRL-5935	2249
NCI-H1570		678		NCI-H2342	CRL-5941	2249
NCI-H1653		678		NCI-H2347	CRL-5970	2249
NCI-H1725		678		NCI-H810	CRL-5816	678

Table II : cell lines with p53 gene deletion or rearrangement

Cell line	ATCC	Reference
NCI-H1299	CRL-5803
H-358	CRL5807
Calu-1	HTB-54

Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)

Cell line	ATCC	Mutation	reference
NCI-H648	CRL-5834	intron7	92
NCI-H1710		intron8	92
NCI-H920	CRL-5850	intron5	92
NCI-H1792	CRL-5895	c.672+1G>A	92

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
229	TGT	TGA	Cys	Stop	SM	866MT	6	16	Single report
278	CCT	TCT	Pro	Ser	SM	ABC-1	87	1382	Single report
71	CCC	del1	Pro	Fs.	SM	ACC-LC-319	2	1976	Single report
281	GAC	GGC	Asp	Gly	SM	ACC-LC94	16	1976	Single report
209	AGA	TGA	Arg	Stop	SM	CAEP	14	1393	Single report
135	TGC	TTC	Cys	Phe	SM	CAL-12T	52	2249	Mutation in COSMIC database
280	AGA	AAA	Arg	Lys	SM	Ca-Lu-1	78	1081	Single report
237	ATG	ATT	Met	Ile	SM	CALU-3	52	2249	Mutation in COSMIC database
196	CGA	TGA	Arg	Stop	SM	CALU6	241	16	Single report
175	CGC	CAC	Arg	His	SM	CMRC-LCD	1187	1382	Single report
171	GAG	TAG	Glu	Stop	SM	EBC-1	25	1382	Single report
187	GGT	del111	Gly	InF	SM	EKVX	1	1018	Controversy with other publications
203	GTG	GTT	Val	Val	SM	EKVX	2	2249	Controversy with other publications
204	GAG	TAG	Glu	Stop	SM	EKVX	46	2249	Controversy with other publications
273	CGT	TGT	Arg	Cys	SM	GLCA2	687	1386	Single report
248	CGG	CTG	Arg	Leu	DMU	GLCP1	124	1386	Single report
349	GAA	TAA	Glu	Stop	DMU	GLCP1	7	1386	Single report
139	AAG	del1c	Lys	Fs.	SM	HCC1438	1	1327	Single report
154	GGC	GTC	Gly	Val	SM	HCC2108	65	1327	Single report
234	TAC	TGC	Tyr	Cys	SM	HCC2279	133	1327	Single report
175	CGC	CTC	Arg	Leu	SM	HOP-92	25	1018	Confirmed in COSMIC database
132	AAG	AAT	Lys	Asn	SM	IGR-Heu	23	2195	Single report
249	AGG	AGT	Arg	Ser	SM	KNS-62	389	2249	Mutation in COSMIC database
237	ATG	ATT	Met	Ile	SM	LC-1-SQ	52	364	Confirmed in another publication
241	TCC	TGC	Ser	Cys	SM	LC-2-ad	36	2249	Mutation in COSMIC database
216	GTG	TTG	Val	Leu	SM	LCLC-103H	13	2249	Mutation in COSMIC database
248	CGG	CTG	Arg	Leu	SM	LCMS	124	1382	Single report
272	GTG	ATG	Val	Met	SM	LK-2	105	1006	Single report
11	GAG	CAG	Glu	Gln	SM	LU-65	10	1382	Single report
273	CGT	CAT	Arg	His	SM	LX-1	780	1081	Single report
248	CGG	TGG	Arg	Trp	SM	LXF-289	728	2249	Mutation in COSMIC database
248	CGG	CAG	Arg	Gln	SM	MA1	883	1382	Confirmed in another publication
245	GGC	GTC	Gly	Val	SM	MA-10	84	1382	Single report
282	CGG	TGG	Arg	Trp	SM	MA14	600	1574	Single report
175	CGC	CAC	Arg	His	SM	MA2	1187	1382	Confirmed in another publication
337	CGC	TGC	Arg	Cys	SM	MA-24	19	1382	Single report
237	ATG	ATA	Met	Ile	SM	MA25	123	1382	Confirmed in another publication
121	TCT	del1c	Ser	Fs.	SM	MA-29	1	1382	Single report
245	GGC	TGC	Gly	Cys	SM	MA3	86	1382	Confirmed in another publication
245	GGC	GTC	Gly	Val	SM	MA36	84	1574	Single report
273	CGT	CAT	Arg	His	SM	NCI-H1155	780	92	Confirmed in two other publications
239	AAC	ins1b	Asn	Fs.	SM	NCI-H125	1	678	Single report
298	GAG	TAG	Glu	Stop	SM	NCI-H1264	71	92	Single report
248	CGG	TGG	Arg	Trp	SM	NCI-H1284	728	678	Single report
234	TAC	TGC	Tyr	Cys	SM	NCI-H1304	133	678	wt in COSMIC
224	GAG	GAC	Glu	Asp	SM	NCI-H1334	10	92	Single report
285	GAG	AAG	Glu	Lys	SM	NCI-H1355	165	92	Confirmed in another publication
47	CCG	CTG	Pro	Leu	SM	NCI-H1373	3	106	Controversy with other publications
144	CAG	TAG	Gln	Stop	SM	NCI-H1404	53	92	Single report
141	TGC	TGG	Cys	Trp	SM	NCI-H1435	11	92	Single report
267	CGG	CCG	Arg	Pro	SM	NCI-H1437	19	92	Confirmed in another publication
89	CCC	del1	Pro	Fs.	SM	NCI-H1466	3	92	Single report
34	CCC	ins1	Pro	Fs.	DMU	NCI-H157	1	1382	Controversy with other publications
282	CGG	CCG	Arg	Pro	SM	NCI-H157	21	2021	Controversy with other publications
298	GAG	TAG	Glu	Stop	SM	NCI-H157	71	92	Controversy with other publications
298	GAG	TAG	Glu	Stop	DMU	NCI-H157	71	1382	Controversy with other publications
248	CGG	CTG	Arg	Leu	SM	NCI-H1573	124	92	Single report
144	CAG	TAG	Gln	Stop	SM	NCI-H1581	53	92	wt in COSMIC
273	CGT	CTT	Arg	Leu	SM	NCI-H1623	147	92	Single report
175	CGC	CAC	Arg	His	SM	NCI-H1628	1187	678	Single report
35	TTG	ins1b	Leu	Fs.	SM	NCI-H1648	1	92	wt in COSMIC
176	TGC	TAC	Cys	Tyr	SM	NCI-H1651	88	92	Single report
285	GAG	AAG	Glu	Lys	SM	NCI-H1703	165	92	Controversy with other publications
273	CGT	CTT	Arg	Leu	SM	NCI-H1734	147	92	wt in COSMIC
242	TGC	TTC	Cys	Phe	SM	NCI-H1755	88	92	Single report
247	AAC	AAT	Asn	Asn	SM	NCI-H1770	39	2249	Mutation in COSMIC database
248	CGG	TGG	Arg	Trp	SM	NCI-H1770	728	2249	Mutation in COSMIC database
157	GTC	TTC	Val	Phe	SM	NCI-H1781	177	92	Single report
209	AGA	TGA	Arg	Stop	SM	NCI-H1793	14	92	Controversy with other publications
273	CGT	CAT	Arg	His	SM	NCI-H1793	780	2249	Controversy with other publications
273	CGT	CTT	Arg	Leu	SM	NCI-H1838	147	2249	Mutation in COSMIC database
237	ATG	ATA	Met	Ile	SM	NCI-H1869	123	678	Single report
209	AGA	TGA	Arg	Stop	SM	NCI-H1904	14	92	Single report
291	AAG	TAG	Lys	Stop	SM	NCI-H1915	9	92	Single report
242	TGC	TGG	Cys	Trp	SM	NCI-H1993	16	2249	Mutation in COSMIC database
273	CGT	CTT	Arg	Leu	SM	NCI-H2009	147	92	Single report
262	GGT	GTT	Gly	Val	SM	NCI-H2030	14	2249	Mutation in COSMIC database
242	TGC	TGG	Cys	Trp	SM	NCI-H2073	16	92	Single report
220	TAT	TCT	Tyr	Ser	SM	NCI-H2086	20	106	Single report
157	GTC	TTC	Val	Phe	SM	NCI-H2087	177	92	Confirmed in another publication
248	CGG	TGG	Arg	Trp	SM	NCI-H2106	728	106	Single report
16	CAG	CTG	Gln	Leu	DMU	NCI-H2122	1	2249	Mutation in COSMIC database
176	TGC	TTC	Cys	Phe	DMU	NCI-H2122	191	2249	Mutation in COSMIC database
62	GAA	TAA	Glu	Stop	SM	NCI-H2126	8	2249	Mutation in COSMIC database
161	GCC	ACC	Ala	Thr	SM	NCI-H2250	75	92	Single report
158	CGC	CTC	Arg	Leu	SM	NCI-H226	92	92	Controversy with other publications
309	CCC	GCC	Pro	Ala	SM	NCI-H226	1	1018	Controversy with other publications
154	GGC	GTC	Gly	Val	SM	NCI-H2291	65	2249	Mutation in COSMIC database
246	ATG	ATC	Met	Ile	SM	NCI-H23	6	17	Confirmed in another publication
273	CGT	CAT	Arg	His	SM	NCI-H2405	780	2249	Mutation in COSMIC database
248	CGG	CTG	Arg	Leu	SM	NCI-H322	124	92	Confirmed in another publication
249	AGG	AGC	Arg	Ser	SM	NCI-H324	34	678	Controversy with other publications
249	AGG	AGC	Arg	Ser	DMU	NCI-H324	34	92	Controversy with other publications
259	GAC	GTC	Asp	Val	DMU	NCI-H324	21	92	Controversy with other publications
158	CGC	CTC	Arg	Leu	SM	NCI-H441	92	92	Confirmed in another publication. wt in COSMIC
146	TGG	TGA	Trp	Stop	SM	NCI-H520	51	92	wt in COSMIC
191	CCT	del1a	Pro	Fs.	SM	NCI-H522	8	92	Single report
245	GGC	TGC	Gly	Cys	SM	NCI-H596	86	92	Confirmed in another publication
164	AAG	AAT	Lys	Asn	SM	NCI-H650	8	92	Single report
215	AGT	ATT	Ser	Ile	SM	NCI-H661	25	92	wt in COSMIC
217	GTG	TTG	Val	Leu	DMU	NCI-H676	3	92	Single report
248	CGG	CTG	Arg	Leu	DMU	NCI-H676	124	92	Single report
102	ACC	del1	Thr	Fs.	SM	NCI-H679	1	92	Single report
176	TGC	TGG	Cys	Trp	SM	NCI-H720	19	92	wt in COSMIC
162	ATC	ins9c	Ile	InF	SM	NCI-H727	1	1707	Single report
267	CGG	CCG	Arg	Pro	SM	NCI-H738	19	678	Single report
284	ACA	CCA	Thr	Pro	SM	NCI-H820	10	106	Single report
285	GAG	AAG	Glu	Lys	SM	NCI-H854	165	92	Single report
249	AGG	AGT	Arg	Ser	SM	OG56	389	1976	Single report
334	GGG	GTG	Gly	Val	SM	PC-1	3	1382	Single report
245	GGC	TGC	Gly	Cys	SM	PC-10	86	364	Single report
334	GGG	GTG	Gly	Val	SM	PC-13	3	1382	Single report
248	CGG	TGG	Arg	Trp	SM	PC-14	728	1382	Controversy with other publications
248	CGG	CAG	Arg	Gln	SM	PC-14	883	2242	Controversy with other publications
282	CGG	TGG	Arg	Trp	SM	PC-3	600	364	Confirmed in another publication
214	CAT	CGT	His	Arg	SM	PC-7	69	1382	Single report
248	CGG	CAG	Arg	Gln	SM	PC-9	883	364	Single report
104	CAG	TAG	Gln	Stop	SM	PERF-LC-AI	18	1976	Single report
244	GGC	TGC	Gly	Cys	SM	RAL	53	1393	Single report
113	TTC	TGC	Phe	Cys	SM	RERF-LOCK	9	1382	Single report
158	CGC	CTC	Arg	Leu	SM	SK-LC-6	92	1976	Single report
193	CAT	CGT	His	Arg	SM	SKLU1	86	16	Single report
280	AGA	AAA	Arg	Lys	SM	SK-MES-1	78	1081	Controversy with other publications. Excluded from the cosnensus
298	GAG	TAG	Glu	Stop	SM	SK-MES-1	71	303	Consensus based on three publications. Controversy with other publications
277	TGT	TTT	Cys	Phe	SM	SW1271	48	16	Single report
167	CAG	TAG	Gln	Stop	SM	SW900	40	2249	Mutation in COSMIC database
347	GCC	ACC	Ala	Thr	SM	U-1752	3	2021	Single report
175	CGC	del1	Arg	Fs.	SM	U-1810	3	2021	Single report
175	CGC	CAC	Arg	His	SM	VRMC-LCD	1187	1976	Single report
204	GAG	TAG	Glu	Stop	SM	Y-ML-1B	46	1867	Single report

Leukemia / Lymphoma Table I : cell lines with wt p53 Cell line ATCC Origin Ref J-111   AML 1006 IM-9 CCL-159 CML-B 1006 ML-1   CML   KMS-12-BM   Myeloma 1006 KMS-12-PE   Myeloma 1006 RPMI-1788 CCL156 Myeloma 1006 Ly3   Diffuse large cell lymphoma 613 DHL4   Diffuse large cell lymphoma 613 JJN-3   Myeloma 98 XG-3   Myeloma 98 PL-21   Myeloid Leukemia 126 ALL-B   ALL 1303 ALL-G   ALL 1303 ALL-K   ALL 1303 NGR   ALL 1303 SCO-1   ALL 1303 BRE   ALL 1303 HAU   ALL 1303 WMN   Burkitt lymphoma 447 FWL   Lymphoblastoid 447 NL2   Lymphoblastoid 447 AG876   Burkitt lymphoma 447 SHO   Burkitt lymphoma 447 JLP119   Burkitt lymphoma 447 EW36   Burkitt lymphoma 447 Reh CRL-8286 ALL 1627 UoC-B1   ALL 1627 UoC-B3   ALL 1627 UoC-B4   ALL 1627 UoC-B11   ALL 1627 SUP-B7   ALL 1627 SUP-B13   ALL 1627 SUP-B15   ALL 1627 EU-1   ALL 1627 EU-3   ALL 1627 Table II : cell lines with p53 gene deletion or rearrangement Cell line ATCC Origin HL-60 CCL-240 promyelocytic leukemia EU-4   ALL Table III : cell lines with p53 splice mutation (exonic mutations that modify splice are listed in table IV) no data Table IV: cell lines with p53 mutations (missense or frameshift) More information is available in the handbook Pos: Codon position (1 to 393); WT: Normal base sequence of the codon in which the mutation occurred; Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown AA: Wild type amino acid; Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion; Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor; NB: Number of tumors with this particular mutant in the database; Ref: reference number; Comments: information; Table of references (available also in the handbook) Pos. WT Mut       AA Mut Comp Name NB Ref Comments Acute Myelogenous Leukemia 306 CGA TGA Arg Stop SM 2L1 160 2048 from patient RUPN84. Single report 236 TAC CAC Tyr His MM CG2 13 356 Single report 237 ATG GTG Met Val MM CG2 14 356 Single report 248 CGG CAG Arg Gln MM CG2 883 356 Single report 133 ATG AAG Met Lys SM HEL 13 1006 wt in COSMIC 248 CGG TGG Arg Trp SM K051 728 243 Single report 248 CGG TGG Arg Trp SM K052 728 243 Single report 248 CGG CAG Arg Gln SM KASUMI-1 883 2249 Mutation in COSMIC database 272 GTG ATG Val Met SM KMOE-2 105 2249 Mutation in COSMIC database 241 TCC CCC Ser Pro SM ML-1 11 2198 Single report 273 CGT CAT Arg His SM MONOMAC-1 780 2198 Single report 241 TCC del1c Ser Fs. SM NOMO-1 4 2249 Mutation in COSMIC database 172 GTT TTT Val Phe DMU OHN-GM 19 2049 Single report 238 TGT TAT Cys Tyr DMU OHN-GM 98 2049 Single report 195 ATC ACC Ile Thr SM SHI-1 90 2207 Single report 288 AAT TAT Asn Tyr SM YSK-21 5 1710 Single report B-Acute Lymphoblastic Leukemia 109 TTC TCC Phe Ser SM ALL-A 3 1303 Single report 265 CTG CCG Leu Pro SM ALL-C 23 1303 Single report 248 CGG CAG Arg Gln SM ALL-PO 883 2249 Mutation in COSMIC database 109 TTC TCC Phe Ser SM ALL-W 3 1303 Single report 248 CGG CAG Arg Gln SM EU-10 883 1627 Single report 248 CGG CAG Arg Gln SM EU-11 883 1627 Single report 248 CGG CAG Arg Gln SM EU-13 883 1627 Single report 273 CGT CTT Arg Leu SM EU-18 147 1627 Single report 248 CGG CAG Arg Gln SM EU-2 883 617 Single report 273 CGT CTT Arg Leu SM EU-6 147 617 Single report 248 CGG CAG Arg Gln SM EU-7 883 617 Single report 246 ATG ACG Met Thr SM GR-ST 13 2249 Mutation in COSMIC database 124 TGC TGA Cys Stop SM HPB-ALL 1 2198 Single report 273 CGT TGT Arg Cys SM KARPAS-45 687 2249 Mutation in COSMIC database 224 GAG ins5 Glu Fs. SM KG-1 1 126 Single report 225 GTT ATT Val Ile SM KG-1a 4 163 Single report 177 CCC TCC Pro Ser SM KMO-90 19 239 Single report 245 GGC AGC Gly Ser SM KOPM30 440 661 Single report 245 GGC CGC Gly Arg SM KOPN32 20 661 Single report 257 CTG GTG Leu Val SM KOPN35 7 661 Single report 282 CGG ins2b Arg Fs. SM KOPN49 1 661 Single report 209 AGA ins4b Arg Fs. SM KOPN63 1 661 Single report 175 CGC TGC Arg Cys MM SCMC-L9 28 478 Single report 248 CGG CAG Arg Gln MM SCMC-L9 883 478 Single report 358 GAG AAG Glu Lys MM SCMC-L9 1 478 Single report 246 ATG ACG Met Thr SM Tanoue 13 2242 Single report 175 CGC CAC Arg His SM TMBL-1 1187 1967 Single report 220 TAT TGT Tyr Cys SM U-698-M 336 2249 Mutation in COSMIC database B-cell Leukemia 281 GAC GGC Asp Gly SM BALL-1 16 2242 Single report 248 CGG CTG Arg Leu SM HL-60(TB) 124 1018 Single report 132 AAG AGG Lys Arg SM KU812 51 1006 wt in COSMIC 285 GAG AAG Glu Lys SM RPMI-8226 165 1018 Single report 237 ATG ATA Met Ile SM WI-L2-NS 123 637 Controversy with other publications 330 CTT CAT Leu His SM WI-L2-NS 4 769 Controversy with other publications B-cell Lymphoma 280 AGA CGA Arg Arg SM 2 1 1098 Single report 127 TCC TTC Ser Phe SM 3 30 1098 Single report 176 TGC TCC Cys Ser SM 5 13 1098 Single report 248 CGG CAG Arg Gln SM 6 883 1098 Single report 273 CGT TGT Arg Cys SM 8 687 1098 Single report 274 GTT CTT Val Leu SM 9 16 1098 Single report 213 CGA CAA Arg Gln DMD A3/KAW 38 3 Single report 234 TAC CAC Tyr His DMD A3/KAW 25 3 Single report 283 CGC CAC Arg His SM DG-75 19 1143 Single report 216 GTG ATG Val Met DMU HT 74 2249 Mutation in COSMIC database 273 CGT CAT Arg His DMU HT 780 2249 Mutation in COSMIC database 158 CGC CAC Arg His DMU LY1 105 613 Single report 176 TGC GGC Cys Gly DMU LY1 7 613 Single report 238 TGT CGT Cys Arg SM LY17 26 613 Single report 176 TGC TTC Cys Phe SM LY2 191 613 Single report 245 GGC GAC Gly Asp SM LY7 171 613 Single report 282 CGG CCG Arg Pro SM LY8 C3 21 613 Single report B-Lineage Diffuse Large Cell Leukemia 248 CGG CAG Arg Gln SM DB 883 2249 Mutation in COSMIC database 273 CGT TGT Arg Cys SM KARPAS-299 687 2249 Mutation in COSMIC database 319 AAG TAG Lys Stop SM KARPAS-422 5 2249 Mutation in COSMIC database Burkitt lymphoma 273 CGT TGT Arg Cys SM Abana 687 2247 Single report 190 CCT del1 Pro Fs. SM AKATA 1 75 Single report 248 CGG CAG Arg Gln SM AKUA 883 447 Single report 206 TTG del1 Leu Fs. SM AS283A 2 44 Single report 193 CAT CGT His Arg SM BJAB 86 75 Single report 273 CGT TGT Arg Cys SM BL-113 687 44 Single report 246 ATG ACG Met Thr SM BL-30 13 75 Single report 237 ATG ATA Met Ile SM BL-37 123 44 Single report 248 CGG CAG Arg Gln SM BL-41 883 75 Single report 176 TGC TAC Cys Tyr DMU BL-49 88 44 Single report 248 CGG TGG Arg Trp DMU BL-49 728 44 Single report 282 CGG TGG Arg Trp SM BL-60 600 44 Single report 273 CGT TGT Arg Cys SM BL-70 687 2249 Mutation in COSMIC database 213 CGA TGA Arg Stop SM BL-99 306 44 Single report 248 CGG CAG Arg Gln SM CA46 883 447 Single report 175 CGC CAC Arg His SM CW678 1187 44 Single report 213 CGA TGA Arg Stop SM DAUDI 306 44 Controversy with other publications 266 GGA GAA Gly Glu SM DAUDI 74 2249 Controversy with other publications 248 CGG CAG Arg Gln SM DH978 883 1030 Single report 206 TTG del1 Leu Fs. SM EB3 2 44 Single report 152 CCG CTG Pro Leu DMD GA-10 91 1819 Single report 232 ATC AAC Ile Asn DMD GA-10 13 1819 Single report 234 TAC TGC Tyr Cys SM JD38 133 44 Confirmed in another publication 132 AAG CAG Lys Gln SM JIYOYE 14 75 Confirmed in another publication 248 CGG CAG Arg Gln SM KK124 883 1007 Single report 248 CGG CAG Arg Gln SM KK125 883 44 Single report 238 TGT TAT Cys Tyr SM LOUCKES 98 75 Confirmed in another publication 238 TGT TAT Cys Tyr SM MC116 98 44 Confirmed in another publication 248 CGG CAG Arg Gln SM NAMALWA 883 75 Confirmed in three other publications 163 TAC CAC Tyr His DMU P3HR1 26 44 Confirmed in two other publications 287 GAG TAG Glu Stop DMU P3HR1 14 44 Confirmed in two other publications 273 CGT TGT Arg Cys SM PP984 687 44 Single report 213 CGA CAA Arg Gln DMD RAJI 38 161 Confirmed in another publication Some publications described only one of the two mutations 234 TAC CAC Tyr His DMD RAJI 25 161 Confirmed in another publication Some publications described only one of the two mutations 254 ATC GAC Ile Asp SM RAMOS 3 44 Confirmed in three other publications 175 CGC ins3a Arg InF SM SG568 1 447 Single report 158 CGC CAC Arg His SM ST486 105 44 Consensus based on three puublications. Controversy with other publications Second mutation found by COSMIC 158 CGC CAC Arg His DMU ST486 105 2249 Controversy with other publications. Excluded from the consensus 239 AAC GAC Asn Asp DMU ST486 53 2249 Controversy with other publications. Excluded from the consensus Chronic Myelocytic Leukemia 289 CTC CAC Leu His SM CG3 2 356 Single report 136 CAA ins1a Gln Fs. SM K-562 1 269 Confirmed in another publication 301 CCA DEL1 Pro Fs. SM KCL-22 2 150 Single report 248 CGG CAG Arg Gln SM KYO-1 883 150 Single report 319 AAG TAG Lys Stop SM LAMA-84 5 2249 Mutation in COSMIC database Erythroleukemia 274 GTT GAT Val Asp SM OCIM2 8 12 Single report Hodgkin disease 175 CGC CAC Arg His DMD CO 1187 55 Single report 282 CGG TGG Arg Trp DMD CO 600 55 Single report 232 ATC del11c Ile Fs. SM HD-MY-Z 1 2249 Mutation in COSMIC database Lymphoid leukemia 273 CGT TGT Arg Cys SM RPMI-8402 687 163 Single report Mantle Cell Lymphoma 147 GTT GGT Val Gly SM Mino 8 1842 Single report Merkel cell carcinoma 241 TCC TTT Ser Phe DMU MCC13 6 2088 Single report 278 CCT TCT Pro Ser DMU MCC13 87 2088 Single report 272 GTG GAG Val Glu SM MCC14/2 12 2088 Single report Multiple Myeloma 255 ATC del6b Ile InF SM MEF-1 2 1363 Single report Myelodysplastic synd. 248 CGG CAG Arg Gln SM SKM-1 883 1363 Single report Myeloid leukemia 175 CGC CAC Arg His SM KY821 1187 126 wt in COSMIC 251 ATC DEL1B Ile Fs. SM TF-1 5 126 Single report 174 AGG DEL26A Arg Fs. SM THP-1 1 126 Confirmed in another publication 172 GTT DEL46A Val Fs. SM U937 2 126 Single report 261 AGT DEL99A Ser InF SM UT7 1 126 Single report Myeloma 273 CGT CAT Arg His SM ARH-77 780 2249 Mutation in COSMIC database 132 AAG AAC Lys Asn SM EJM 33 98 Single report 143 GTG ATG Val Met SM HD-70 34 1004 Single report 337 CGC CTC Arg Leu SM KMS-12-PE 9 2249 Mutation in COSMIC database 261 AGT ACT Ser Thr SM L-363 1 2249 Mutation in COSMIC database 184 GAT TAT Asp Tyr SM LB 831 5 98 Single report 286 GAA AAA Glu Lys SM LP-1 86 2249 Mutation in COSMIC database 285 GAG AAG Glu Lys SM RPMI-8226 165 98 Single report 161 GCC ACC Ala Thr SM U266 75 98 Single report 126 TAC AAC Tyr Asn SM XG-1 6 98 Single report 176 TGC TAC Cys Tyr SM XG-2 88 98 Single report 181 CGC TGC Arg Cys SM XG-4 28 98 Single report 282 CGG TGG Arg Trp SM XG-5 600 98 Single report NK-Leukemia 248 CGG TGG Arg Trp SM KHYG-1 728 1125 Single report Non-Hodgkin's Lymphomas 237 ATG ATA Met Ile DMD OCI-Ly4 123 517 Single report 248 CGG CAG Arg Gln DMD OCI-Ly4 883 517 Single report 248 CGG CAG Arg Gln SM WSU-NHL 883 2249 Mutation in COSMIC database T-cell Acute Lymphoblastic Leukemia 37 TCC CCC Ser Pro MM CCRF-CEM-VLB100 1 1703 Single report 175 CGC CAC Arg His MM CCRF-CEM-VLB100 1187 1703 Single report 248 CGG CAG Arg Gln MM CCRF-CEM-VLB100 883 1703 Single report 196 CGA TGA Arg Stop DMU J-RT3-T3-5 241 2249 Mutation in COSMIC database 360 GGG del1a Gly Fs. DMU J-RT3-T3-5 2 2249 Mutation in COSMIC database 196 CGA TGA Arg Stop MM JURKAT 241 3 Single report 256 ACA GCA Thr Ala MM JURKAT 9 3 Single report 259 GAC GGC Asp Gly MM JURKAT 6 3 Single report 260 TCC GCC Ser Ala MM JURKAT 4 3 Single report 272 GTG ATG Val Met SM Loucy 105 1510 Single report 273 CGT CAT Arg His SM MOLT-13 780 2249 Mutation in COSMIC database 237 ATG AGG Met Arg DMU MOLT-16 8 3 wt in COSMIC 244 GGC TGC Gly Cys DMU MOLT-16 53 3 wt in COSMIC 111 CTG GTG Leu Val SM MOLT-4 1 2242 Controversy with other publications 248 CGG CAG Arg Gln SM MOLT-4 883 27 Controversy with other publications 306 CGA TGA Arg Stop SM MOLT-4 160 2249 Controversy with other publications 11 GAG CAG Glu Gln MM P12-ICHIKAWA 10 2249 Mutation in COSMIC database 248 CGG CCG Arg Pro MM P12-ICHIKAWA 23 2249 Mutation in COSMIC database 248 CGG CAG Arg Gln MM P12-ICHIKAWA 883 2249 Mutation in COSMIC database 273 CGT TGT Arg Cys SM PF-382 687 2249 Mutation in COSMIC database 248 CGG CAG Arg Gln MM SUP-T1 883 2249 Mutation in COSMIC database 267 CGG CTG Arg Leu MM SUP-T1 1 2249 Mutation in COSMIC database 273 CGT CAT Arg His MM SUP-T1 780 2249 Mutation in COSMIC database T-cell leukemia 278 CCT TCT Pro Ser SM ATL1K 87 82 Single report 175 CGC GGC Arg Gly SM HATL 27 323 Single report 176 TGC TAC Cys Tyr SM MT1 88 82 Single report T-cell Lymphoma 196 CGA TGA Arg Stop SM HUT78 241 3 Single report