Head and Neck SCC

Table I : cell lines with wt p53

Cell line	ATCC	Ref.		Cell line	ATCC	Ref.
MO24		2252
PCI-30		2252		UPCI-SCC-154		1544
UM-SCC-17A/B		2252		HOC927		105
UM-SCC-25		2252		BICR-10		208
UM-SCC-47		2252		BICR-18		208
UM-SCC-72		2252		MSK-922		600
UM-SCC-74A		2252		MSK-121		600
UM-SCC-74B		2252		MDA-1986		600
UM-SCC-81A		2252		MDA-886		600
UPCI-SCC-3		1544		584		600
UPCI-SCC-30		1544		185		600
UPCI-SCC-40		1544		1483		600
UPCI-SCC-56		1544		183A		600
UPCI-SCC-81		1544		NHOK		626
UPCI-SCC-104		1544		HOK-16B		626
UPCI-SCC-131		1544		HOK-18A		626
UPCI-SCC-142		1544		HAp-2		626

Table II : cell lines with p53 gene deletion or rearrangement

No data

Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)

Cell line	ATCC	Mutation	reference
HSC-2		Splice intron 6	105
BICR-22		Splice intron 8	208
NU		Splice intron 6	105

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
175	CGC	CAC	Arg	His	SM	Detroit562	1187	2249	Mutation in COSMIC database
281	GAC	CAC	Asp	His	SM	TYS	41	1056	Single report
258	GAA	AAA	Glu	Lys	SM	4197	73	1076	Single report
180	GAG	del1b	Glu	Fs.	SM	A253	1	2249	Mutation in COSMIC database
275	TGT	TGG	Cys	Trp	SM	A30	11	2032	Single report
183	TCA	TAA	Ser	Stop	SM	BB30-HNC	3	2249	Mutation in COSMIC database
146	TGG	TGA	Trp	Stop	SM	BICR-16	51	208	Single report
332	ATC	del99	Ile	InF	SM	BICR-19	1	208	Single report
308	CTG	del19	Leu	Fs.	SM	BICR-22	1	208	Single report
282	CGG	CCG	Arg	Pro	SM	BICR-3	21	208	Single report
173	GTG	del3b	Val	InF	SM	BICR-31	2	208	Single report
126	TAC	del21	Tyr	InF	SM	BICR-56	4	208	Single report
192	CAG	TAG	Gln	Stop	SM	BICR-6	85	208	Single report
151	CCC	CAC	Pro	His	SM	BICR-7	33	208	Single report
248	CGG	TGG	Arg	Trp	SM	Ca9-22	728	105	Single report
193	CAT	CTT	His	Leu	SM	CAL-27	55	1854	Single report
175	CGC	CAC	Arg	His	SM	CAL-33	1187	2249	Mutation in COSMIC database
188	CTG	del12	Leu	InF	SM	DOK	1	418	Single report
213	CGA	TGA	Arg	Stop	SM	EVSCC1	306	153	Single report
248	CGG	CTG	Arg	Leu	SM	FaDu	124	153	Confirmed in two other publications
248	CGG	TGG	Arg	Trp	SM	FS-1	728	2252	Single report
267	CGG	TGG	Arg	Trp	SM	GL	37	1846	Single report
193	CAT	CTT	His	Leu	SM	HN	55	2249	Mutation in COSMIC database
266	GGA	CGA	Gly	Arg	SM	HO-1-N-1	20	2249	Mutation in COSMIC database
285	GAG	AAG	Glu	Lys	SM	HOC313	165	105	Single report
126	TAC	TAG	Tyr	Stop	SM	HOC605	14	105	Single report
281	GAC	GAG	Asp	Glu	SM	HOC719	26	105	Single report
205	TAT	TGT	Tyr	Cys	SM	HOC815	117	105	Single report
305	AAG	ins1a	Lys	Fs.	SM	HSC-3	1	105	Single report
248	CGG	CAG	Arg	Gln	SM	HSC-4	883	105	Single report
237	ATG	ATA	Met	Ile	SM	HSC-5	123	105	Single report
266	GGA	GAA	Gly	Glu	SM	HSQ-89	74	2252	Single report
194	CTT	CGT	Leu	Arg	SM	HU 281	66	202	Single report
298	GAG	TAG	Glu	Stop	SM	JSQ-3	71	160	Single report
52	CAA	ins3a	Gln	InF	SM	KOSC-2	1	2249	Mutation in COSMIC database
248	CGG	TGG	Arg	Trp	SM	KOSC-3	728	598	Single report
176	TGC	TGG	Cys	Trp	SM	KUMA-3	19	2252	Single report
179	CAT	CGT	His	Arg	SM	LB771-HNC	146	2249	Mutation in COSMIC database
258	GAA	GGA	Glu	Gly	SM	MDA-1186	20	600	Single report
280	AGA	CCA	Arg	Pro	DMU	MDA-1386	1	600	Single report
282	CGG	TGG	Arg	Trp	DMU	MDA-1386	600	600	Single report
126	TAC	TGC	Tyr	Cys	SM	MDA-1483	17	2032	Single report
273	CGT	CTT	Arg	Leu	SM	MDA-1586	147	600	Single report
218	GTG	GGG	Val	Gly	DMU	MDA-1686	11	600	Single report
256	ACA	del1c	Thr	Fs.	DMU	MDA-1686	1	600	Single report
151	CCC	TCC	Pro	Ser	SM	MDA-183	92	2032	Single report
151	CCC	TCC	Pro	Ser	SM	MDA-686	92	600	Confirmed in another publication
283	CGC	CCC	Arg	Pro	SM	MKG 7	35	1846	Single report
244	GGC	AGC	Gly	Ser	SM	MSK-QLL1	72	600	Single report
196	CGA	TGA	Arg	Stop	SM	MSK-QLL2	241	600	Single report
220	TAT	CAT	Tyr	His	SM	NA	15	105	Single report
248	CGG	TGG	Arg	Trp	SM	NOS-1	728	1784	wt in COSMIC
132	AAG	GAG	Lys	Glu	SM	OC2	25	1854	Single report
173	GTG	TTG	Val	Leu	SM	OC3	68	2224	Single report
266	GGA	GAA	Gly	Glu	SM	OM1	74	105	Single report
283	CGC	CGG	Arg	Arg	MM	OSC-1	5	1207	Single report
299	CTG	CTA	Leu	Leu	MM	OSC-1	2	1207	Single report
346	GAG	AAG	Glu	Lys	MM	OSC-1	1	1207	Single report
280	AGA	ACA	Arg	Thr	SM	OSC-2	92	1207	Single report
116	TCT	TCC	Ser	Ser	DMU	OSC-3	2	1207	Single report
176	TGC	TTC	Cys	Phe	DMU	OSC-3	191	1207	Single report
174	AGG	AGA	Arg	Arg	SM	OSC-4	7	1207	Single report
150	ACA	GCA	Thr	Ala	DMU	OSC-5	3	1207	Single report
190	CCT	CCC	Pro	Pro	DMU	OSC-5	2	1207	Single report
95	TCT	CCT	Ser	Pro	DMU	OSC-6	1	1207	Single report
126	TAC	TAG	Tyr	Stop	DMU	OSC-6	14	1207	Single report
54	TTC	TAC	Phe	Tyr	SM	OSC-7	2	1207	Single report
193	CAT	TAT	His	Tyr	DMU	OSC-8	41	1207	Single report
256	ACA	ATA	Thr	Ile	DMU	OSC-8	6	1207	Single report
273	CGT	CAT	Arg	His	DMU	OSC-9	780	1207	Single report
309	CCC	ACC	Pro	Thr	DMU	OSC-9	2	1207	Single report
286	GAA	AAA	Glu	Lys	SM	PCI-13	86	2252	Single report
336	GAG	TAG	Glu	Stop	SM	SAS	5	2249	Mutation in COSMIC database
216	GTG	GGG	Val	Gly	SM	SCC-12B	5	208	Single report
258	GAA	AAA	Glu	Lys	SM	SCC-13	73	208	Single report
224	GAG	ins5c	Glu	Fs.	SM	SCC-15	1	626	Single report
209	AGA	del2a	Arg	Fs.	SM	SCC-25	20	208	Confirmed in COSMIC database
175	CGC	CAC	Arg	His	SM	SCC-27	1187	208	Single report
273	CGT	CAT	Arg	His	SM	SCC-35	780	160	Single report
151	CCC	TCC	Pro	Ser	SM	SCC-4	92	208	Confirmed in another publication
258	GAA	AAA	Glu	Lys	SM	SCC-4451	73	1937	Single report
274	GTT	del32c	Val	Fs.	SM	SCC-9	1	2249	Mutation in COSMIC database
249	AGG	AGC	Arg	Ser	SM	SKX	34	1846	Single report
196	CGA	TGA	Arg	Stop	SM	SQ-38	241	160	Single report
271	GAG	del1	Glu	Fs.	SM	SQ9G	2	160	Single report
151	CCC	TCC	Pro	Ser	SM	SSC-4	92	202	Single report
274	GTT	del32	Val	Fs.	SM	SSC-9	1	160	Single report
248	CGG	TGG	Arg	Trp	SM	TSU	728	105	Single report
171	GAG	del46c	Glu	Fs.	SM	TU-139	1	626	Single report
151	CCC	TCC	Pro	Ser	SM	TU-177	92	626	Single report
224	GAG	TAG	Glu	Stop	SM	UD-SCC-3	10	1636	Single report
222	CCG	del13	Pro	Fs.	SM	UD-SCC-4	1	1636	Single report
179	CAT	TAT	His	Tyr	SM	UD-SCC-5	128	1636	Single report
220	TAT	TGT	Tyr	Cys	SM	UD-SCC-6	336	1636	Single report
248	CGG	CTG	Arg	Leu	SM	UD-SCC-7	124	1636	Single report
155	ACC	AAC	Thr	Asn	SM	UD-SCC-8	34	1636	Single report
349	GAA	TAA	Glu	Stop	SM	UMB-SCC-745	7	2245	Single report
270	TTT	del1a	Phe	Fs.	SM	UMB-SCC-864	3	2245	Single report
205	TAT	CAT	Tyr	His	SM	UMB-SCC-969	12	2245	Single report
245	GGC	TGC	Gly	Cys	SM	UM-SCC-10A	86	153	Single report
245	GGC	TGC	Gly	Cys	SM	UM-SCC-10B	86	153	Single report
242	TGC	TCC	Cys	Ser	SM	UM-SCC-11B	19	1636	Single report
104	CAG	TAG	Gln	Stop	SM	UM-SCC-12	18	1983	Single report
163	TAC	TGC	Tyr	Cys	SM	UM-SCC-13	140	1983	Single report
277	TGT	del30	Cys	InF	SM	UM-SCC-14	2	1019	Controversy with other publications
277	TGT	del30	Cys	InF	DMU	UM-SCC-14	2	1636	Controversy with other publications
280	AGA	AGT	Arg	Ser	DMU	UM-SCC-14	14	1636	Controversy with other publications
248	CGG	CTG	Arg	Leu	SM	UM-SCC-16	124	153	Single report
148	GAT	del10	Asp	Fs.	SM	UM-SCC-19	2	153	Single report
71	CCC	del2a	Pro	Fs.	SM	UM-SCC-20	1	1983	Single report
220	TAT	TGT	Tyr	Cys	SM	UM-SCC-22	336	2245	Single report
176	TGC	TTC	Cys	Phe	SM	UM-SCC-23	191	153	Single report
273	CGT	TGT	Arg	Cys	SM	UM-SCC-27	687	2245	Single report
248	CGG	CAG	Arg	Gln	SM	UM-SCC-3	883	2245	Single report
158	CGC	CCC	Arg	Pro	SM	UM-SCC-36	21	1983	Single report
213	CGA	TGA	Arg	Stop	SM	UM-SCC-4	306	2245	Single report
278	CCT	GCT	Pro	Ala	SM	UM-SCC-46	24	1983	Single report
157	GTC	TTC	Val	Phe	SM	UM-SCC-5	177	2248	Single report
273	CGT	CTT	Arg	Leu	SM	UM-SCC-57	147	1983	Single report
242	TGC	TTC	Cys	Phe	SM	UM-SCC-63	88	153	Single report
248	CGG	TGG	Arg	Trp	SM	UM-SCC-68	728	1983	Single report
193	CAT	CGT	His	Arg	SM	UM-SCC-81B	86	1983	Single report
306	CGA	TGA	Arg	Stop	SM	UPCI:SCC-103	160	1544	Single report
155	ACC	CCC	Thr	Pro	SM	UPCI:SCC-105	20	1544	Single report
179	CAT	TAT	His	Tyr	SM	UPCI:SCC-111	128	1544	Single report
248	CGG	CAG	Arg	Gln	SM	UPCI:SCC-114	883	1544	Single report
175	CGC	CAC	Arg	His	SM	UPCI:SCC-116	1187	1544	Single report
273	CGT	CAT	Arg	His	SM	UPCI:SCC-122	780	1544	Single report
151	CCC	CAC	Pro	His	SM	UPCI:SCC-125	33	1544	Single report
224	GAG	TAG	Glu	Stop	SM	UPCI:SCC-136	10	1544	Single report
282	CGG	TGG	Arg	Trp	SM	UPCI:SCC-16	600	1544	Single report
155	ACC	CCC	Thr	Pro	SM	UPCI:SCC-172	20	1544	Single report
294	GAG	TAG	Glu	Stop	SM	UPCI:SCC-182	54	1544	Single report
280	AGA	ACA	Arg	Thr	SM	UPCI:SCC-29B	92	1544	Single report
195	ATC	TTC	Ile	Phe	SM	UPCI:SCC-36	29	1544	Single report
248	CGG	CAG	Arg	Gln	SM	UPCI:SCC-70	883	1544	Single report
179	CAT	AAT	His	Asn	SM	UPCI:SCC-72	23	1544	Single report
177	CCC	CGC	Pro	Arg	SM	UPCI:SCC-99	19	1544	Single report
196	CGA	TGA	Arg	Stop	SM	UT-SCC-1	241	1019	Single report
144	CAG	TAG	Gln	Stop	DMU	UT-SCC-10	53	1019	Single report
306	CGA	TGA	Arg	Stop	DMU	UT-SCC-10	160	1019	Single report
342	CGA	TGA	Arg	Stop	SM	UT-SCC-12	74	2250	Single report
110	CGT	TGT	Arg	Cys	DMU	UT-SCC-16	11	1019	Single report
232	ATC	AAC	Ile	Asn	DMU	UT-SCC-16	13	1019	Single report
285	GAG	AAG	Glu	Lys	SM	UT-SCC-19	165	2250	Single report
275	TGT	TTT	Cys	Phe	SM	UT-SCC-2	47	1019	Single report
248	CGG	TGG	Arg	Trp	SM	UT-SCC-20	728	1019	Single report
238	TGT	TTT	Cys	Phe	SM	UT-SCC-22	42	1636	Single report
282	CGG	CCG	Arg	Pro	SM	UT-SCC-30	21	1019	Single report
282	CGG	TGG	Arg	Trp	SM	UT-SCC-33	600	1636	Single report
248	CGG	del9	Arg	InF	SM	UT-SCC-4	1	2250	Single report
151	CCC	CAT	Pro	His	SM	UT-SCC-5	3	1019	Single report
266	GGA	GAA	Gly	Glu	SM	UT-SCC-7	74	2250	Single report
255	ATC	TTC	Ile	Phe	SM	UT-SCC-8	37	2250	Single report
273	CGT	CTT	Arg	Leu	SM	VU1131	147	1996	Single report
282	CGG	TGG	Arg	Trp	SM	VU1365	600	1996	Single report
236	TAC	TAA	Tyr	Stop	SM	YD-10B	12	2189	Single report
258	GAA	GCA	Glu	Ala	SM	YD-15	3	2189	Single report
273	CGT	CAT	Arg	His	SM	YD-8	780	2189	Single report
279	GGG	GAG	Gly	Glu	SM	ZA	42	105	Single report

Esophageal cancer

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

Esophageal adenocarcinoma

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
273	CGT	AGT	Arg	Ser	DMU	Bic-1	20	2004	Single report
309	CCC	TCC	Pro	Ser	DMU	Bic-1	6	2004	Single report
277	TGT	TTT	Cys	Phe	SM	Flo-1	48	2004	Single report
310	AAC	ins1a	Asn	Fs.	SM	OE19	1	2249	Mutation in COSMIC database

Esophageal SCC

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
248	CGG	TGG	Arg	Trp	SM	COLO-680N	728	2249	Mutation in COSMIC database
234	TAC	TGC	Tyr	Cys	SM	EC-GI-10	133	2249	Mutation in COSMIC database
245	GGC	GTC	Gly	Val	SM	HCE-4	84	5	wt in COSMIC
278	CCT	TCT	Pro	Ser	SM	HCE-6	87	5	Single report
278	CCT	TCT	Pro	Ser	SM	HCE7	87	1317	Single report
220	TAT	TGT	Tyr	Cys	SM	KYSE- 890	336	634	Single report
337	CGC	TGC	Arg	Cys	SM	KYSE-110	19	634	Single report
193	CAT	CTT	His	Leu	DMU	KYSE-1170	55	634	Single report
255	ATC	GTC	Ile	Val	DMU	KYSE-1170	4	634	Single report
194	CTT	GTT	Leu	Val	SM	KYSE-1240	3	634	Single report
193	CAT	CTT	His	Leu	SM	KYSE-1250	55	634	Single report
342	CGA	del7a	Arg	Fs.	SM	KYSE-1260	1	634	Single report
193	CAT	CGT	His	Arg	SM	KYSE-140	86	634	Single report
248	CGG	CAG	Arg	Gln	SM	KYSE-150	883	2249	Mutation in COSMIC database
266	GGA	CGA	Gly	Arg	SM	KYSE-170	20	634	Single report
195	ATC	ACC	Ile	Thr	SM	KYSE-180	90	2249	Mutation in COSMIC database
203	GTG	CTG	Val	Leu	SM	KYSE-190	2	634	Single report
337	CGC	TGC	Arg	Cys	SM	KYSE-200	19	634	Single report
248	CGG	TGG	Arg	Trp	SM	KYSE-220	728	634	Single report
248	CGG	CAG	Arg	Gln	SM	KYSE-350	883	634	Single report
337	CGC	TGC	Arg	Cys	SM	KYSE-410	19	2249	Mutation in COSMIC database
179	CAT	CGT	His	Arg	SM	KYSE-450	146	634	Controversy with other publications
339	GAG	TAG	Glu	Stop	SM	KYSE-450	12	2249	Controversy with other publications
241	TCC	del32c	Ser	Fs.	SM	KYSE-510	1	634	Controversy with other publications
343	GAG	TAG	Glu	Stop	SM	KYSE-510	5	2249	Controversy with other publications
266	GGA	CGA	Gly	Arg	SM	KYSE-590	20	634	Single report
251	ATC	ins1a	Ile	Fs.	SM	KYSE-70	1	634	Single report
273	CGT	TGT	Arg	Cys	SM	KYSE-850	687	634	Single report
175	CGC	CAC	Arg	His	SM	SK-GT-4	1187	462	Single report
214	CAT	CGT	His	Arg	SM	T.T	69	1006	Single report
272	GTG	ATG	Val	Met	SM	T.Tn	105	1006	Single report
272	GTG	ATG	Val	Met	SM	TE-1	105	1144	wt in COSMIC
242	TGC	TAC	Cys	Tyr	SM	TE-10	58	1144	Single report
110	CGT	CTT	Arg	Leu	SM	TE-11	28	1006	Controversy with other publications. wt in COSMIC
237	ATG	ATT	Met	Ile	SM	TE-11	52	1144	Controversy with other publications. wt in COSMIC
342	CGA	TGA	Arg	Stop	SM	TE-15	74	2249	Mutation in COSMIC database
248	CGG	CAG	Arg	Gln	SM	TE-6	883	1144	Single report
237	ATG	ATT	Met	Ile	SM	TE-8	52	2249	Mutation in COSMIC database
267	CGG	del1b	Arg	Fs.	SM	TE-9	2	1144	wt in COSMIC

Colorectal carcinoma

Table I : cell lines with wt p53

Cell line	ATCC	Reference
C32		2051
C99		2051
COLO678		2051
Gp2D		2051
HCT116	CCL-247	2051
LOVO	CCL-229	2051
LS180	CL-187	2051
LS174T	CL-188	2051
LS513	CRL-2134	2051
NCI-747		2051
RKO	CRL-2577	2051
SKCO-1	HTB-39	2051
Col15		2251
TC7		2251
EB		2251

Table II : cell lines with p53 gene deletion or rearrangement

No data

Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)

no data

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

Colorectal adenoma

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
282	CGG	TGG	Arg	Trp	SM	RG	600	1	Single report
248	CGG	TGG	Arg	Trp	SM	VACO330	728	1	Single report

Colorectal carcinoma

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
301	CCA	del1a	Pro	Fs.	SM	ala	6	724	Single report
245	GGC	AGC	Gly	Ser	SM	C10	440	2051	Single report
125	ACG	ATG	Thr	Met	SM	C106	12	2051	Single report
196	CGA	TGA	Arg	Stop	SM	C125-PM	241	2051	Single report
249	AGG	AGC	Arg	Ser	SM	C75	34	2051	Single report
52	CAA	TAA	Gln	Stop	SM	C80	6	2051	Single report
342	CGA	TGA	Arg	Stop	SM	C84	74	2051	Single report
204	GAG	TAG	Glu	Stop	SM	CACO2	46	2051	Single report
234	TAC	TGC	Tyr	Cys	SM	CaR-1	133	1006	Controversy with other publications. wt in COSMIC
272	GTG	ATG	Val	Met	SM	CaR-1	105	2051	Controversy with other publications. wt in COSMIC
245	GGC	AGC	Gly	Ser	SM	CBS	440	724	Single report
245	GGC	AGC	Gly	Ser	SM	CC07	440	2051	Single report
126	TAC	TAG	Tyr	Stop	SM	CC20	14	2051	Single report
278	CCT	CAT	Pro	His	SM	CCK-81	13	2051	Single report
241	TCC	TTC	Ser	Phe	SM	CLONE A	101	492	Single report
241	TCC	TTC	Ser	Phe	SM	CLONE D	101	492	Single report
134	TTT	TTG	Phe	Leu	SM	Co74	6	2258
193	CAT	CGT	His	Arg	SM	Co82	86	2258
144	CAG	TAG	Gln	Stop	SM	Co84	53	2258
273	CGT	TGT	Arg	Cys	SM	Co92	687	2258
196	CGA	TGA	Arg	Stop	SM	CoCM-1	241	2051	Single report
103	TAC	del27	Tyr	InF	SM	COLO-205	1	492	Controversy with other publications
266	GGA	GAA	Gly	Glu	SM	COLO-205	74	1018	Controversy with other publications
248	CGG	TGG	Arg	Trp	SM	COLO-320	728	38	Confirmed in two other publications
321	AAA	ins2a	Lys	Fs.	SM	COLO-741	1	2051	Single report
273	CGT	CAT	Arg	His	SM	CX-1	780	492	Single report
248	CGG	CAG	Arg	Gln	SM	CX27	883	1	Single report
241	TCC	TTC	Ser	Phe	SM	DLD-1	101	27	Confirmed in three other publications
176	TGC	TTC	Cys	Phe	SM	FET	191	724	Single report
277	TGT	TTT	Cys	Phe	SM	FRI	48	724	Single report
245	GGC	GAC	Gly	Asp	SM	GLY	171	724	Single report
273	CGT	CAT	Arg	His	SM	H-110	780	1689	Single report
306	CGA	TGA	Arg	Stop	SM	H-173	160	1689	Single report
272	GTG	del2b	Val	Fs.	SM	HCA46	1	2051	Single report
300	CCC	del1a	Pro	Fs.	SM	HCA7	8	2051	Single report
213	CGA	TGA	Arg	Stop	SM	HCC-2998	306	1018	Confirmed in COSMIC database
153	CCC	GCC	Pro	Ala	SM	HCT-15	5	1018	Controversy with other publications
241	TCC	TTC	Ser	Phe	SM	HCT-15	101	2251	Controversy with other publications
273	CGT	CAT	Arg	His	SM	HRA19	780	2051	Single report
273	CGT	CAT	Arg	His	SM	HT-29	780	492	Confirmed in two other publications
213	CGA	CTA	Arg	Leu	SM	HT55	33	2051	wt in COSMIC
163	TAC	CAC	Tyr	His	SM	ISRECO1	26	724	Single report
72	CCC	del1b	Pro	Fs.	SM	KM12	1	2249	Controversy with other publications
179	CAT	CGT	His	Arg	SM	KM12	146	1018	Controversy with other publications
234	TAC	CAC	Tyr	His	SM	LIM1863	25	2051	Single report
245	GGC	GAC	Gly	Asp	SM	LS-1034	171	724	Single report
175	CGC	CAC	Arg	His	SM	LS-123	1187	2051	Single report
126	TAC	TAA	Tyr	Stop	SM	LS-411	11	2051	Single report
241	TCC	TTC	Ser	Phe	SM	MIP 101	101	492	Single report
161	GCC	ACC	Ala	Thr	SM	MOSER	75	492	Single report
273	CGT	CAT	Arg	His	SM	NCI-H508	780	2249	Mutation in COSMIC database
342	CGA	TGA	Arg	Stop	SM	NCI-H630	74	2249	Mutation in COSMIC database
224	GAG	GAT	Glu	Asp	SM	NCI-H716	6	2051	wt in COSMIC
158	CGC	CTC	Arg	Leu	SM	NCI-H747	92	219	Single report
272	GTG	ATG	Val	Met	SM	P-6	105	1006	Single report
306	CGA	TGA	Arg	Stop	SM	RCM-1	160	2051	Single report
190	CCT	CTT	Pro	Leu	SM	SNU-1033	52	1204	Single report
248	CGG	TGG	Arg	Trp	SM	SNU-1040	728	1204	Single report
254	ATC	ACC	Ile	Thr	SM	SNU-1047	11	1204	Single report
175	CGC	CAC	Arg	His	SM	SNU-1097	1187	1204	Single report
273	CGT	CTT	Arg	Leu	SM	SNU-503	147	1204	Single report
175	CGC	CAC	Arg	His	SM	SNU-61	1187	1204	Single report
166	TCA	TGA	Ser	Stop	SM	SNU-C1	18	2249	Mutation in COSMIC database
273	CGT	TGT	Arg	Cys	DMD	SNU-C2B	687	2051	Single report
273	CGT	CAT	Arg	His	DMD	SNU-C2B	780	2051	Single report
218	GTG	TTG	Val	Leu	DMD	SNU-C5	3	1038	Single report
248	CGG	TGG	Arg	Trp	DMD	SNU-C5	728	1038	Single report
159	GCC	GAC	Ala	Asp	SM	SW1116	8	219	Confirmed in two other publications. wt in COSMIC
237	ATG	del14	Met	Fs.	SM	SW1417	1	492	wt in COSMIC
248	CGG	CAG	Arg	Gln	SM	SW1463	883	2249	Mutation in COSMIC database
51	GAA	TAA	Glu	Stop	SM	SW403	6	2051	Single report
248	CGG	TGG	Arg	Trp	SM	SW48	728	492	Confirmed in another publication. wt in COSMIC
273	CGT	CAT	Arg	His	DMU	SW480	780	9	Single report
309	CCC	TCC	Pro	Ser	DMU	SW480	6	9	Single report
248	CGG	TGG	Arg	Trp	SM	SW837	728	9	Confirmed in two other publications
117	GGG	del1a	Gly	Fs.	SM	SW948	3	2051	wt in COSMIC
245	GGC	GAC	Gly	Asp	SM	V9P	171	724	Single report
175	CGC	CAC	Arg	His	SM	VACO10MS	1187	2051	Single report
306	CGA	TGA	Arg	Stop	SM	VACO429	160	2051	Single report
154	GGC	AGC	Gly	Ser	SM	VACO457	14	996	Single report
135	TGC	TGG	Cys	Trp	SM	VACO489	25	996	Single report
329	ACC	ins1a	Thr	Fs.	SM	VACO4A	1	2051	Single report
282	CGG	TGG	Arg	Trp	SM	VACO5	600	996	Single report
273	CGT	TGT	Arg	Cys	SM	VACO576	687	996	Single report
181	CGC	TGC	Arg	Cys	SM	VACO670	28	996	Single report
190	CCT	CTT	Pro	Leu	SM	VACO8	52	996	Single report
273	CGT	CAT	Arg	His	SM	WIDR	780	27	Confirmed in another publication

Cervical cancer

Table I : cell lines with wt p53

Cell line	ATCC	Reference
HeLa*	CCL-2	1006
ME-180*	HTB-33	1006
SKG-IIIa*		1006
SW756*	CRL-10302	2249
CA-SKI*	CRL-1550	2249
SIHA*	HTB-35	2249
KB*	CCL-17	2249
MS-715*	HTB-34	68
C4II*	CRL-1595	68
SKG-II*

* HPV positive
Table II : cell lines with p53 gene deletion or rearrangement
no data
Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)
no data
Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook
Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;
Table of references (available also in the handbook)

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
109	TTC	TTA	Phe	Leu	SM	C2	1	469	Single report
273	CGT	TGT	Arg	Cys	SM	C33A	687	54	Confirmed in two other publications
245	GGC	GTC	Gly	Val	SM	HT-3	84	54	Confirmed in another publication
175	CGC	CAC	Arg	His	SM	IGR/Cut40	1187	573	Single report
131	AAC	del3a	Asn	InF	SM	SKS	7	1782	Single report

Breast carcinoma

Table I : cell lines with wt p53

Cell line	ATCC	Reference
MCF-7	HTB-22	2091
MCF10-2A
DU4475	HTB-123	2091
MDA-MB-175VII	HTB-25	2091
MPE600		2091
SK-BR-7		2091
SUM102PT		2091
UACC-812	CRL-1897	2091
ZR75-1	CRL-1500	2091
ZR75-30	CRL-1504	2091
HBL-100*		2029
MRK-NU-1		1006
YMB-1		1006
YMB-1-E		1006

*Positive for SV40

Table II : cell lines with p53 gene deletion or rearrangement

Cell line	ATCC	Reference
MDA- MB-157	HTB-24

Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)

no data

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

Pos.	WT	Mut	AA	Mut	Comp	Name	NB	Ref	Comments
179	CAT	AAT	His	Asn	SM	3522 S2	23	1017	Single report
266	GGA	TGA	Gly	Stop	SM	BRC-230	19	1393	Single report
132	AAG	CAG	Lys	Gln	SM	BT-20	14	24	Confirmed in another publication. wt in COSMIC
285	GAG	AAG	Glu	Lys	SM	BT-474	165	24	Confirmed in three other publications
246	ATG	del1c	Met	Fs.	SM	BT-483	1	2029	Controversy with other publications
246	ATG	ATA	Met	Ile	SM	BT-483	33	2091	Controversy with other publications
249	AGG	AGC	Arg	Ser	SM	BT-549	34	24	Single report
224	GAG	AAG	Glu	Lys	SM	CAL-148	8	2249	Mutation in COSMIC database
132	AAG	GAG	Lys	Glu	SM	CAL-85-1	25	2249	Mutation in COSMIC database
280	AGA	ACA	Arg	Thr	SM	CAMA-1	92	2029	wt in COSMIC
241	TCC	TGC	Ser	Cys	SM	EVSA-T	36	2091	wt in COSMIC
248	CGG	CAG	Arg	Gln	SM	H-31	883	1689	Single report
262	GGT	GTT	Gly	Val	SM	H-71	14	1689	Single report
281	GAC	CAC	Asp	His	SM	HCC1007	41	1396	Single report
281	GAC	TAC	Asp	Tyr	SM	HCC1008	16	2258
248	CGG	CAG	Arg	Gln	SM	HCC1143	883	2249	Mutation in COSMIC database
248	CGG	CAG	Arg	Gln	SM	HCC1143	883	2258
108	GGT	del3b	Gly	InF	SM	HCC1187	1	2258
108	GGT	del3a	Gly	InF	SM	HCC1187	1	2249	Mutation in COSMIC database
175	CGC	CAC	Arg	His	SM	HCC1395	1187	1396	Single report
175	CGC	CAC	Arg	His	SM	HCC1395	1187	2258
74	GCC	del6a	Ala	InF	DMU	HCC1419	1	2249	Mutation in COSMIC database
220	TAT	TGT	Tyr	Cys	DMU	HCC1419	336	2249	Mutation in COSMIC database
294	GAG	TAG	Glu	Stop	SM	HCC1569	54	1396	Single report
256	ACA	ins2	Thr	Fs.	SM	HCC1806	2	1396	Single report
306	CGA	TGA	Arg	Stop	SM	HCC1937	160	1396	Confirmed in another publication
306	CGA	TGA	Arg	Stop	SM	HCC1937	160	2258
163	TAC	TGC	Tyr	Cys	SM	HCC1954	140	2258
163	TAC	TGC	Tyr	Cys	SM	HCC1954	140	2249	Mutation in COSMIC database
248	CGG	TGG	Arg	Trp	SM	HCC2157	728	2249	Mutation in COSMIC database
248	CGG	TGG	Arg	Trp	SM	HCC2157	728	2258
283	CGC	TGC	Arg	Cys	SM	HCC2218	27	1396	Single report
241	TCC	del1b	Ser	Fs.	SM	HCC2713	26	2258
213	CGA	TGA	Arg	Stop	SM	HCC2998	306	2249	Mutation in COSMIC database
273	CGT	CTT	Arg	Leu	SM	HCC38	147	1396	Single report
273	CGT	CTT	Arg	Leu	SM	HCC38	147	2258
248	CGG	CAG	Arg	Gln	SM	HCC70	883	1396	Single report
213	CGA	TGA	Arg	Stop	SM	HDQ-P1	306	1713	Single report
249	AGG	GGG	Arg	Gly	SM	HMT-3909	52	552	Single report
157	GTC	TTC	Val	Phe	SM	Hs 578T	177	76	Confirmed in two other publications
157	GTC	TTC	Val	Phe	SM	HS578T	177	2258
215	AGT	ATT	Ser	Ile	SM	L56BR-X1	25	1968	Single report
244	GGC	AGC	Gly	Ser	SM	MAST	72	1393	Single report
285	GAG	AAG	Glu	Lys	SM	MDA-MB-134-VI	165	2029	wt in COSMIC
261	AGT	del26a	Ser	Fs.	SM	MDA-MB-157	1	2029	wt in COSMIC
280	AGA	AAA	Arg	Lys	SM	MDA-MB-231	78	24	Confirmed in another publication
220	TAT	TGT	Tyr	Cys	SM	MDA-MB-330	336	2091	Single report
166	TCA	TAA	Ser	Stop	SM	MDA-MB-361	19	2029	wt in COSMIC
236	TAC	TGC	Tyr	Cys	SM	MDA-MB-415	75	2091	Single report
266	GGA	GAA	Gly	Glu	SM	MDA-MB-435	74	1018	Single report
204	GAG	ins7c	Glu	Fs.	SM	MDA-MB-436	1	2029	Controversy with other publications
273	CGT	CAT	Arg	His	SM	MDA-MB-436	780	1367	Controversy with other publications
368	CAC	del30	His	InF	SM	MDA-MB-453	1	147	wt in COSMIC
273	CGT	CAT	Arg	His	SM	MDA-MB-468	780	9	Confirmed in another publication
132	AAG	AGG	Lys	Arg	SM	MFM-223	51	2249	Mutation in COSMIC database
234	TAC	TAA	Tyr	Stop	SM	MW1C-6.3	10	147	Single report
244	GGC	AGC	Gly	Ser	SM	OCUB-F	72	2091	Single report
244	GGC	AGC	Gly	Ser	SM	OCUB-M	72	2249	Mutation in COSMIC database
277	TGT	TTT	Cys	Phe	SM	R11T	48	1806	Single report
136	CAA	TAA	Gln	Stop	SM	R18T	47	1806	Single report
273	CGT	TGT	Arg	Cys	SM	R30T	687	1806	Single report
175	CGC	CAC	Arg	His	SM	SK-BR-3	1187	76	Confirmed in another publication. wt in COSMIC
161	GCC	GAC	Ala	Asp	SM	SK-BR-5	19	2091	Single report
135	TGC	TTC	Cys	Phe	SM	SUM1315MO2	52	2091	Single report
237	ATG	ATA	Met	Ile	SM	SUM149PT	123	2091	Single report
158	CGC	ins3a	Arg	InF	SM	SUM159PT	1	2091	Single report
144	CAG	TAG	Gln	Stop	SM	SUM185PE	53	2091	Single report
317	CAG	TAG	Gln	Stop	SM	SUM190PT	25	2091	Single report
265	CTG	CCG	Leu	Pro	SM	SUM225CWN	23	2091	Single report
273	CGT	TGT	Arg	Cys	SM	SUM229PE	687	2091	Single report
213	CGA	TGA	Arg	Stop	SM	SUM52PE	306	2091	Single report
194	CTT	TTT	Leu	Phe	SM	T47D	28	9	Confirmed in another publication
342	CGA	TGA	Arg	Stop	SM	UACC-893	74	2029	Single report