The effects of hesperetin on apoptosis induction and inhibition of cell
Hesperetin kháng PC3
From Wikipedia, the free encyclopedia
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| Names | |
|---|---|
| IUPAC name
(S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
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| Identifiers | |
3D model (JSmol)
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| ChEBI | |
| ChemSpider | |
| DrugBank | |
| ECHA InfoCard | 100.007.538 |
| EC Number | 208-290-2 |
| KEGG | |
PubChem CID
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| UNII | |
| Properties | |
| C16H14O6 | |
| Molar mass | 302.28 g·mol−1 |
| Melting point | 226–228 °C (439–442 °F; 499–501 K) |
| Solubility in other solvents | Sol. EtOH, alkalis |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| Infobox references | |
Hesperetin is the 4'-methoxy derivative of eriodictyol, a flavanone. Hesperetin's 7-O-glycoside, hesperidin, is a naturally occurring flavanon-glycoside, the main flavonoid in lemons and sweet oranges.[1] Hesperetin (and naringenin, the parent flavanone of naringin) are not found to a significant extent in Citrus spp.[2]
Contents
[hide]Glycosides[edit]
A variety of glycosides of hesperetin are known, including:
- Hesperidin (hesperetin-7-O-rutinoside) is a water-insoluble flavonoid glycoside whose solubility is below 5 μg/ml in water.[3] Hesperidin is found in citrus fruits and upon ingestion it releases its aglycone, hesperetin.
- Neohesperidin is the 7-O-neohesperidoside of hesperetin.
- Hesperetin-7-O-α-L-Rhamnopyranoside (CAS 66513-83-5) is found in the roots of clammy cherry [4] (Cordia obliquaa.k.a. Cordia obliqua var. wallichii[5]).
Metabolism[edit]
Hesperidin 6-O-α-L-rhamnosyl-β-D-glucosidase is an enzyme that uses hesperidin and H2O to produce hesperetin and rutinose. It is found in the hyphomycetes species Stilbella fimetaria.
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