Decursin Suppresses Human Androgen-Independent PC3 Prostate ..
Angelica gigas ( decursin) kháng PC3
From Wikipedia, the free encyclopedia
| Angelica gigas | |
|---|---|
 | |
| Scientific classification | |
| Kingdom: | Plantae |
| (unranked): | Angiosperms |
| (unranked): | Eudicots |
| (unranked): | Asterids |
| Order: | Apiales |
| Family: | Apiaceae |
| Genus: | Angelica |
| Species: | A. gigas |
| Binomial name | |
| Angelica gigas Nakai | |
Angelica gigas, also called Korean angelica,[1] giant Angelica, purple parsnip, and dangquai, is a monocarpic biennial or short lived perennial plant from China, Japan and Korea. It inhabits forests, grasslands and banks of streams. The roots are used in traditional Chinese medicine.
Description[edit]
Angelica gigas is a stout plant that is 1 to 2 meters high with deep thick roots and purplish ribbed stem. Its leaf blades have a triangular-ovate outline. Korean Angelica has a 20–40 × 20–30 cm, 2–3-ternate-pinnate arrangement. The plant's purple umbelmeasures 5–8 cm across. Its dark purple-red obovate flowers,[dubious ] blooms in late summer.
Cultivation[edit]
Giant Angelica prefers moist soil and full sun or semishade. The plant is best propagated through seeds in the spring. The plant is a perennial that flowers in the months of July to August.[2]
Chemical components[edit]
Research in 2007 has isolated a chemical from the root of the plant, a coumarinderivative called decursin, that may have anti-androgenic properties in vitro.[3] In 2013, the main substance decursin, decursinol angelate (its isomer), JH714 (the ether form) and epoxide decursin (the epoxide form) were analyzed in vitro and in vivo. CYPisoforms were inhibited more than 50%. There was good blood brain barrierpermeability in rats after oral administration of all but epoxide. Pharmacokinetic studies after oral and intravenous administration of 10 mg/kg showed that after 8 hours all test compounds stayed in the gastrointestinal tract at more than 1.5% of the dose and less than 0.5% was excreted in urine.[4]
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