[HTML] Reversal effect of bufalin on multidrug resistance in human hepatocellular carcinoma BEL-7402/5-FU cells
Bufalin kháng Bel-7402
From Wikipedia, the free encyclopedia
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| Names | |
|---|---|
| IUPAC name
(3β,5β)-3,14-Dihydroxybufa-20,22-dienolide
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
| Properties | |
| C24H34O4 | |
| Molar mass | 386.53 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| Infobox references | |
Bufalin, is a cardiotonic steroid originally isolated from the Chinese toad venom. It is a component found in many Chinese traditional medicine.[1][2]
Usage[edit]
Bufalin has a in vitro antitumor effects against various malignancies, including hepatocellular[3] and lung carcinoma.[4]However, as with other bufadienolides, its use is hampered by its cardiotoxicity.[5]
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