Friday, 18 August 2017

Eschscholzia californica (Berberine) dược liệu kháng L1210

Eschscholzia californica (Berberine) dược liệu kháng L1210

From Wikipedia, the free encyclopedia
California poppy
Kaldari Eschscholzia californica 01.jpg

Apparently Secure (NatureServe)
Scientific classification
Kingdom:Plantae
(unranked):Angiosperms
(unranked):Eudicots
Order:Ranunculales
Family:Papaveraceae
Genus:Eschscholzia
Species:E. californica
Binomial name
Eschscholzia californica
Cham.
Eschscholzia californica (California poppyCalifornian poppy,[1] golden poppyCalifornia sunlightcup of gold) is a species of flowering plant in the Papaveraceae familynative to the United States and Mexico. It is an ornamental plant and it is used medicinally and in cooking, and it became the official state flower of California in 1903.

Description[edit]

It is a perennial or annual plant growing to 5–60 in (13–152 cm) tall with alternately branching glaucous blue-green foliage. The leaves are alternately divided into round, lobed segments. The flowers are solitary on long stems, silky-textured, with four petals, each petal 2 to 6 cm (0.79 to 2.36 in) long and broad; flower color ranges through yellow, orange and red [2] (with some pinks [3]), with flowering from February to September in the northern hemisphere (spring, summer, autumn). The petals close at night (or in cold, windy weather) and open again the following morning, although they may remain closed in cloudy weather.[4]The fruit is a slender, dehiscent capsule 3 to 9 cm (1.2 to 3.5 in) long, which splits in two to release numerous small black or dark brown seeds. It survives mild winters in its native range, dying completely in colder climates.
Botanical illustration
California poppy seeds

Habitat[edit]

Its native habitat includes California and extends to Oregon, Washington, Nevada, Arizona, New Mexico, Sonora and northwest Baja California.[4] The Antelope Valley California Poppy Reserve is located in northern Los Angeles County. At the peak of the blooming season, orange flowers seem to cover all 1,745 acres (706 ha) of the reserve. Other prominent locations of California poppy meadows are in Bear Valley (Colusa County) and Point Buchon (San Luis Obispo County).
Antelope Valley California Poppy Reserve
Bear Valley

Taxonomy[edit]

E. californica subsp. mexicana, Mexican gold poppy, Maricopa County, Arizona
Eschscholzia californica was the first named species of the genus Eschscholzia, named by the German botanist Adelbert von Chamisso after the Baltic German botanist Johann Friedrich von Eschscholtz, his friend and colleague on Otto von Kotzebue’s scientific expedition to California and the greater Pacific circa 1810 aboard the Russian ship Rurik.
Maritime poppies, E. californica subsp. californica var. maritima (E. L. Greene) Jeps., Cambria, California.
California poppy is highly variable, with over 90 synonyms. Some botanists accept two subspecies — one with four varieties (e.g., Leger and Rice, 2003) — though others do not recognize them as distinct (e.g., Jepson 1993):
  • E. californica subsp. californica, native to California, Baja California, and Oregon, widely planted as an ornamental, and an invasive elsewhere (see below).
    • E. californica subsp. californica var. californica, which is found along the coast from the San Francisco Peninsula north. They are perennial and somewhat prostrate, with yellow flowers.
    • E. californica subsp. californica var. maritima (E. L. GreeneJeps., which is found along the coast from Monterey south to San Miguel Island. They are perennial, long-lived, glaucous, short in stature, and have extremely prostrate growth and yellow flowers.
    • E. californica subsp. californica var. crocea (Benth.) Jeps., which grows in non-arid inland regions. They are perennial, taller, and have orange flowers.
    • E. California subsp. californica var. peninsularis (E. L. Greene) Munz, which is an annual or facultative annual growing in arid inland environments.
  • E. californica subsp. mexicana (E. L. GreeneC. Clark, the Mexican Gold Poppy, which is found in the Sonoran Desert. Some authorities refer to it as E. Mexicana. [5]

Uses[edit]

California poppy leaves were used medicinally by Native Americans and the pollen was used cosmetically, while the seeds continue to be used in cooking.[4][dead link]
The plant is used as an herbal remedy: an aqueous extract of the plant has sedative and anxiolytic actions.[6] The extract acts as a mild sedative when smoked, but the effect is far milder than that of opium because California poppy contains a different class of alkaloids:[7][8]
"An aqueous alcohol extract of Eschscholzia californica has been evaluated for benzodiazepine, neuroleptic, antidepressant, antihistaminic and analgesic properties. The plant extract did not protect mice against the convulsant effects of pentylenetetrazol, and did not cause muscle relaxant effects, but appeared to possess an affinity for the benzodiazepine receptor. The extract induced peripheral analgesic effects in mice but did not possess antidepressant, neuroleptic or antihistaminic effects."[9]

Cultivation[edit]

E. californica is drought-tolerant, self-seeding, and easy to cultivate. It is best grown as an annual in full sun and sandy, well-drained, poor soil. Horticulturalists have produced numerous cultivars with a range of colors and blossom and stem forms. These typically do not breed true on reseeding. Seeds are often sold as mixtures. The following cultivars have gained the Royal Horticultural Society's Award of Garden Merit:-
  • 'Appleblossom Bush'[10] (pink with red streaks)
  • 'Apricot Chiffon'[11] (yellow flushed with pink and orange)
  • 'Dali'[12] (red)
  • 'Rose Chiffon'[13] (pink and white)
Genetic variation in blossom color
'Purple Gleam'
'Ivory Castle'

Invasive potential[edit]

Because of its beauty and ease of growing, the California poppy was introduced into several regions with similar Mediterranean climates. It is commercially sold and widely naturalized in Australia, and was introduced to South Africa, Chile, and Argentina. It is recognized as a potentially invasive species within the United States, although no indications of ill effects have been reported for this plant where it has been introduced outside of California. The golden poppy has been displaced in large areas of its original habitat, such as Southern California, by more invasive exotic species, such as mustard or annual grasses.

Chilean population[edit]

In Chile, it was introduced from multiple sources between the mid-19th century and the early 20th century. It appears to have been both intentionally imported as an ornamental garden plant, and accidentally introduced along with alfalfa seed grown in California. Since Chile and California have similar climatic regions and have experienced much agricultural exchange, it is perhaps not surprising that it was introduced to Chile. Once there, its perennial forms spread primarily in human-disturbed environments (Leger and Rice, 2003).
Interestingly, the introduced Chilean populations of California poppy appear to be larger and more fecund in their introduced range than in their native range (Leger and Rice, 2003). Introduced populations have been noted to be larger and more reproductively successful than native ones (Elton, 1958), and there has been much speculation as to why. Increase in resource availability, decreased competition, and release from enemy pressure have all been proposed as explanations.
One hypothesis is that the plant's resources devoted in the native range to a defense strategy can, in the absence of enemies, be devoted to increased growth and reproduction (the EICA Hypothesis, Blossey & Nötzold, 1995). However, this is not the case with introduced populations of E. californica in Chile: the Chilean populations were actually more resistant to Californian caterpillars than native populations (Leger and Forister, 2005).
Highway sign showing the state flower

State flower of California[edit]

During the 1890s Sarah Plummer Lemmon advocated for the adoption of the golden poppy as the state flower of California, eventually writing the bill passed by the California Legislature and signed by Governor George Pardee in 1903.[14][15][16]
As the official state flower of California, Eschscholzia californica is pictured on welcome signs along highways entering California[17] and official Scenic Route signs.
It was selected as the state flower by the California State Floral Society in December 1890, besting the Mariposa lily (genus Calochortus) and the Matilija poppy (Romneya coulteri) by a wide margin, but the state legislature did not make the selection official until 1903. Its golden blooms were deemed a fitting symbol for the Golden State.
April 6 is designated as California Poppy Day.

See also[edit]

  • Californidine, a chemical compound found in Eschscholzia californica

Argemone mexicana (Berberine) dược liệu kháng L1210

Argemone mexicana (Berberine) dược liệu kháng L1210

From Wikipedia, the free encyclopedia
Argemone mexicana
Argemone mexicana flower 2.jpg
Scientific classification
Kingdom:Plantae
(unranked):Angiosperms
(unranked):Eudicots
Order:Ranunculales
Family:Papaveraceae
Genus:Argemone
Species:A. mexicana
Binomial name
Argemone mexicana
L.
Argemone.mexicana001.jpg
Indian Argemone Mexicana
Argemone mexicana (Mexican poppy,[1] Mexican prickly poppyflowering thistle,[2] cardo or cardosanto) is a species of poppy found in Mexico and now widely naturalized in many parts of the world. An extremely hardy pioneer plant, it is tolerant of drought and poor soil, often being the only cover on new road cuttings or verges. It has bright yellow latex, and though poisonous to grazing animals, is rarely eaten, but has been used medicinally by many people including those in its native area, the Natives of the western US and parts of Mexico.[3]

Chemical constituents[edit]

A. mexicana seeds contain 22–36% of a pale yellow non-edible oil, called argemone oil or katkar oil, which contains the toxic alkaloids sanguinarine and dihydrosanguinarine. Four quaternary isoquinoline alkaloids, dehydrocorydalminejatrorrhizinecolumbamine, and oxyberberine, have been isolated from the whole plant of Argemone mexicana.[4]
The seed pods secrete a pale yellow latex when cut open. This argemone resin contains berberine and protopine.

Toxicity[edit]

The seeds resemble the seeds of Brassica nigra (mustard). As a result, mustard can be adulterated by argemone seeds, rendering it poisonous. Several significant instances of katkar poisoning have been reported in IndiaFijiSouth Africa and other countries. The last major outbreak in India occurred in 1998. 1% adulteration of mustard oil by argemone oil has been shown to cause clinical disease.[5] in India, Argemone oil is mixed with sunflower oil and sesame oil to increase the quantity, but this adulteration causes health disorders and renowned brands display "no argemone oil" to qualify purity.[6]
Katkar oil poisoning causes epidemic dropsy, with symptoms including extreme swelling, particularly of the legs.

Traditional medicine[edit]

The Seri of SonoraMexico use the entire plant both fresh and dried. An infusion is made to relieve kidney pain, to help expel a torn placenta, and in general to help cleanse the body after parturition.[3]
When the Spanish arrived in Sonora they added this plant to their pharmacopia and called it cardosanto, which should not be mistranslated to blessed thistle (Cnicus benedictus). The seeds are taken as a laxative.[7]
An Argemone mexicana tea is used by traditional healers in Mali to treat malaria. The whole plant is used to make a tea and as much tea as possible is drunk until symptoms disappear.[8] This use has been studied clinically for the treatment of uncomplicated malaria.[9][10] In one study, 73% of patients treated had an adequate clinical response, but very few patients had complete parasite clearance.[11] Another study found that use of Argemone mexicana may be a suitable first-aid treatment in rural areas when access to other better antimalarials is delayed.[12]

Other uses[edit]

Biodiesel production from A. mexicana seed oil using crystalline manganese carbonate has been demonstrated.[citation needed]

See also[edit]

Tinospora cordifolia (Berberine) dược liệu kháng L1210

Tinospora cordifolia (Berberine) dược liệu kháng L1210

From Wikipedia, the free encyclopedia
Tinospora cordifolia
Tinospora cordifolia.jpg
Scientific classification
Kingdom:Plantae
(unranked):Angiosperms
(unranked):Eudicots
Order:Ranunculales
Family:Menispermaceae
Genus:Tinospora
Species:T. cordifolia
Binomial name
Tinospora cordifolia
(Thunb.) Miers
Tinospora cordifolia, which is known by the common names heart-leaved moonseed,[1] guduchi and giloy, is an herbaceous vine of the family Menispermaceae indigenous to the tropical areas of IndiaMyanmar and Sri Lanka.

Vernacular names[edit]

There are many common names for this species in different languages. Punjabi: گلو (Gllow), Telugu: తిప్ప తీగ (Tippa-teega), Tamil: சீந்தில் கொடி (Shindilakodi), Malayalam: ചിറ്റമൃത് (Amruthu, Chittamruthu), Kannada: ಅಮೃತ ಬಳ್ಳಿ (Amrutha balli),[14] Khmer: បណ្តូលពេជ្រ (bândaul pich), Sinhala: රසකිද Rasakinda, Thai: บอระเพ็ด (boraphét), Lao: ເຄືອເຂົາຫໍPali: galocī, Hindi:geloy (गिलोय), guruc (गुरुच), gurcha, Gujarati: galac, garo, Sanskrit: guduchi, amrta
, cinnodbhava (छिन्नोद्भवा), Bengali:Gulancha, Marathi: Guduchi (गुडूची), gulvel (गुळवेल), Odia: Guluchi, Myanmar: ဆင်တုံးမနွယ် Nepali: Gurjo (गुर्जो).

Botanical description[edit]

It is a large, deciduous extensively spreading climbing shrub with several elongated twining branches. Leaves simple, alternate, exstipulate, long petioles up to 15 cm long, roundish, pulvinate, both at the base and apex with the basal one longer and twisted partially and half way around. Lamina broadly ovate or ovate cordate, 10–20 cm long or 8– 15 cm broad, 7 nerved and deeply cordate at base, membranous, pubescent above, whitish tomentose with a prominent reticulum beneath. Flowers unisexual, small on separate plants and appearing when plant is leafless, greenish yellow on axillary and terminal racemes. Male flowers clustered, female usually solitary. Sepals 6, free in two series of three each, the outer ones are smaller than the inner. Petals 6 free smaller than sepals, obovate and membranous. Fruits aggregate of 1-3, ovoid smooth drupelets on thick stalk with sub terminal style scars, scarlet or orange coloured.[2]

Chemical composition[edit]

Traditional medicine[edit]


Giloy herbs at Talkatora GardensNew Delhi
In Ayurvedic medicineT. cordifolia is known as “Guduchi” and is considered to be one of the most divine herbs.[3] But there are some reports where the herb was associated with some adverse effects related to pregnancy, breastfeeding, blood sugar levels etc. The plant extract have shown to have anti-lipoxygenase activity.[4]

Ecology[edit]

Endophytic fungi regarded as a fascinating group of organisms colonize the living, internal tissues of their host (usually higher plants) without causing any harmful effects. A recent study has shown that 29 endophytes belonging to different taxa were present in the samples collected from T. cordifolia.[5]
Extracts of the endophytic fungus Nigrospora sphaerica obtained from T. cordifolia were found to have insecticidal properties against the Oriental leafworm moth (Spodoptera litura), a polyphagous pest.[6]