Antitumor Activity of Acriflavine in Lung Adenocarcinoma Cell Line A549

Acriflavine hợp chất kháng A549

From Wikipedia, the free encyclopedia

This article needs more medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. (December 2016)

Acriflavine

Sample of pure acriflavine
Names
IUPAC name 3,6-Diamino-10-methylacridin-10-ium chloride
Other names Acriflavinium chloride (INN)
Identifiers
CAS Number	65589-70-0  10597-46-3 (HCl)
3D model (JSmol)	Interactive image Interactive image
ChEBI	CHEBI:383703
ChemSpider	391386  21018 (HCl)
EC Number	201-668-8
PubChem CID	443101 15558347 (HCl)
UNII	1S73VW819C
InChI[show]
SMILES[show]
Properties
Chemical formula	C14H14ClN3
Molar mass	259.74 g·mol−1
Pharmacology
ATC code	R02AA13 (WHO) QG01AC90 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
verify (what is  ?)
Infobox references

Acriflavine (INN: acriflavinium chloride) is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. It is a dye and it stains the skin and may irritate. The hydrochloride form is more irritating than the neutral form. It is derived from acridine. Commercial preparations are often mixtures with proflavine.^[1] It is known by a variety of commercial names.

Contents

  [hide] 

• 1Uses
  • 1.1Medical use
  • 1.2Other uses
• 2Research
• 3Legal status
  • 3.1Australia
• 4References
• 5External links

Uses[edit]

Medical use[edit]

Acriflavine was developed in 1912 by Paul Ehrlich, a German medical researcher, and was used during the First World War against sleeping sickness and as a topical antiseptic.^[2]

Other uses[edit]

Acriflavine is used in biochemistry for fluorescently labeling high molecular weight RNA.^[1]

It is used as treatment for external fungal infections of aquarium fish.^[3]

Research[edit]

In an animal model, acriflavine has been shown to inhibit HIF-1, which prevents blood vessels growing to supply tumors with blood and interferes with glucose uptake and use.^[4]

Acriflavine might be effective in fighting common cold virus, and also aid the fight against increasingly antibiotic resistant bacteria.^[5][6][7]

Legal status[edit]

Australia[edit]

Acriflavine is a controlled substance in Australia and dependent on situation,^{[clarification needed]} is considered either a Schedule 5 (Caution) or Schedule 7 (Dangerous Poison) substance. The use, storage and preparation of the chemical is subject to strict state and territory laws.^{[citation needed]}

Pinus massoniana bark extract inhibits migration of the lung cancer ...

Pinus massoniana dược liệu kháng A549

From Wikipedia, the free encyclopedia

Masson's pine
Conservation status
Least Concern (IUCN 2.3)
Scientific classification
Kingdom:	Plantae
Division:	Pinophyta
Class:	Pinopsida
Order:	Pinales
Family:	Pinaceae
Genus:	Pinus
Subgenus:	Pinus
Species:	P. massoniana
Binomial name
Pinus massoniana Lamb.

Pinus massoniana (English: Masson's pine, Chinese red pine, horsetail pine; Chinese: 马尾松) is a species of pine, native to Taiwan, and a wide area of central and southern China, including Hong Kong, and northern Vietnam, growing at low to moderate altitudes, mostly below 1,500 m but rarely up to 2,000 m altitude.^[1]

Contents

  [hide] 

• 1Description
• 2Ecology
• 3Uses
• 4Culture
• 5Notes
• 6References

Description[edit]

It is an evergreen tree reaching 25–45 m in height, with a broad, rounded crown of long branches. The bark is thick, greyish-brown, and scaly plated at the base of the trunk, and orange-red, thin, and flaking higher on the trunk. The leaves are needle-like, dark green, with two per fascicle, 12–20 cm long and 0.8–1 mm wide, the persistent fascicle sheath 1.5–2 cm long. The cones are ovoid, 4–7 cm long, chestnut-brown, opening when mature in late winter to 4–6 cm broad. The seeds are winged, 4–6 mm long with a 10–15 mm wing. Pollination is in mid spring, with the cones maturing 18–20 months after.^[2][3][4]

Ecology[edit]

The Pinewood nematode from North America and pine-needle scale insect from Taiwan, have together virtually eliminated the native Pinus massoniana in Hong Kong in the 1970s and 80s.^[5]

Uses[edit]

The species is a common trees in plantation forestry for replacing or compensating of the loss of the natural forest in southern China.^[6] Chinese rosin is obtained mainly from the turpentine of this pine (Pinus massoniana) and slash pine (P. elliottii).

Logs are mainly used to make pulp for paper industry.

Leaves are used to give special smoke flavor to a local black tea, such as Lapsang souchong of Fujian province.

Culture[edit]

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Gallotannin Inhibits the Expression of Chemokines and Inflammatory ...

Gallotannin hợp chất kháng A549

From Wikipedia, the free encyclopedia

A gallotannin is any of a class of molecules belonging to the hydrolysable tannins. Gallotannins are polymers formed when gallic acid, a polyphenol monomer, esterifies and binds with the hydroxyl group of a polyol carbohydrate such as glucose.

Metabolism[edit]

Gallate 1-beta-glucosyltransferase uses UDP-glucose and gallate to produce UDP and 1-galloyl-beta-D-glucose. Beta-glucogallin O-galloyltransferase uses 1-O-galloyl-beta-D-glucose to produce D-glucose and 1-O,6-O-digalloyl-beta-D-glucose. Beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase uses 1-O-galloyl-beta-D-glucose and 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose to produce D-glucose and 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose (1,2,3,4,6-penta-O-galloyl-β-D-glucose, the common precursor of gallotannins and the related ellagitannins^[1]).

Tannase is a key enzyme in the degradation of gallotannins that uses digallic acid and H₂O to produce gallic acid.