Phellodendron amurense (Berberine) dược liệu kháng L1210

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Phellodendron
Phellodendron amurense Morton Arboretum acc. 568-27*3
Scientific classification
Kingdom:	Plantae
(unranked):	Angiosperms
(unranked):	Eudicots
(unranked):	Rosids
Order:	Sapindales
Family:	Rutaceae
Genus:	Phellodendron
Species:	P. amurense
Binomial name
Phellodendron amurense Rupr.[1]

Phellodendron amurense is a species of tree in the family Rutaceae, commonly called the Amur cork tree. It is a major source of huáng bò (Chinese: 黄柏 or 黄檗), one of the 50 fundamental herbs used in traditional Chinese medicine. The Ainu people used this plant, called shikerebe-ni, as a painkiller.^[2]

Native to eastern Asia; northern China, northeast China, Korea, Ussuri, Amur, and Japan, the Amur cork tree is considered invasive in many parts of North America. The State of Massachusetts lists it as a noxious weed.^[3]

Autumn Foliage and Fruit

Contents

  [hide] 

• 1Medicinal use
• 2Oil
• 3Chemistry
• 4Gallery
• 5See also
• 6References
• 7External links

Medicinal use[edit]

Plant as used in Chinese herbology. Note the pictured is a photo of Licorice Root/ GanCao, not Phellodendron. (crude medicine)

This section needs more medical references for verification or relies too heavily on primary sources. Please review the contents of the section and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. (July 2012)

It has been used as a Chinese traditional medicine for the treatment of meningitis, bacillary dysentery, pneumonia, tuberculosis, and liver cirrhosis.^[4][5]

Used orally to treat abdominal pain, diarrhoea, gastroenteritis and urinary tract infections. Berberine has been shown to be effective for the treatment of bacterially-induced diarrhoea and ocular trachoma. and cutaneous leishmaniasis^[6]Phellodendron amurense may protect cartilage against osteoarthritis progression.^[7] It may prove to be a potentially important chemopreventive agent for lung cancer.^[8]

Phellodendron amurense is able to inhibit prostatic contractility suggesting that it may be useful in the treatment of urological disorders caused by prostatic urethral obstruction such as benign prostatic hyperplasia (BPH).^[9] Nexrutine (bark extract from Phellodendron amurense) may have potential to prevent prostate tumor development.^[10]

Proprietary extracts of Magnolia officinalis and Phellodendron amurense may help overweight/obese people.^[11]

Compounds in the leaves (quercetin, quercetin-3-O-beta-D-glucoside, quercetin-3-O-beta-D-galactoside and kaempferol-3-O-beta-D-glucoside) demonstrated significant free radical scavenging activity comparable to vitamin E.^[12]

Oil[edit]

Amur cork tree fruit oil is a pressed oil extracted from the fruit of Phellodendron amurense. The bark of the tree is an important herbal medicine in China. The oil has insecticidal properties similar to pyrethrum.^[13] The oil contains a variety of biologically active substances, including flavonoids (diosmin), alkaloids (berberine, yatroriccin, palmatine), saponins and coumarins. Medicinal applications of the oil include treatment of pancreatitis, reduction of cholesterol and sugar in blood and the treatment of various skin diseases.^[14]

Chemistry[edit]

Essential oils:^[15]

• Fruit oil contains myrcene (62.3-70.3%) and β-caryophyllene (6.8-10.5%)
• Leaf oil contains β-elemol (18.5%) and (Z)-β-ocimene (12.6%)
• Flower oil contains (Z)-β-ocimene (9.5%), β-elemol (9.4%), myrcene (7.8%) and nonacosane (7.7%)

Amurensin, a tert-amyl alcohol derivative of kaempferol 7-O-glucoside, can be found in P. amurense.^[16]

Gallery[edit]

• 

  Leaf
 
• 

  Tree
 
• 

  Bark

See also[edit]

• Amur cork tree fruit oil
• Chinese herbology 50 fundamental herbs
• Sān miáo wán