Friday, 4 August 2017

Diospyros (Betulinic acid) dược liệu kháng HL-60

Diospyros (Betulinic acid) dược liệu kháng HL-60

From Wikipedia, the free encyclopedia
Ebonies
Diospyros mespiliformis, habitus, Jan Celliers Park.jpg
D. mespiliformis
Scientific classification
Kingdom:Plantae
(unranked):Angiosperms
(unranked):Eudicots
(unranked):Asterids
Order:Ericales
Family:Ebenaceae
Genus:Diospyros
L.[1]
Type species
Diospyros lotus
L.
Diversity
About 750 species
Synonyms[1]
  • Cargillia R.Br.
  • Cavanillea Desr.
  • Ebenus Kuntze (nom. illeg.)
  • Embryopteris Gaertn.
  • Guaiacana Duhamel (nom. illeg.)
  • Idesia Scop.
  • Maba J.R.Forst. & G.Forst.
  • Mabola Raf.
  • Macreightia A.DC.
  • Noltia Thonn.
  • Paralea Aubl.
  • Pimia Seem.
  • Rhaphidanthe Hiern ex Gürke
  • Ropourea Aubl.
  • Royena L.
  • Tetraclis Hiern
Diospyros is a genus of over 700 species of deciduous and evergreen treesshrubs and small bushes. The majority are native to the tropics, with only a few species extending into temperate regions. Depending on their nature, individual species are commonly known as ebony or persimmon trees. Some are valued for their hard, heavy, dark timber, and some for their fruit. Some are useful as ornamentals and many are of local ecological importance.

Taxonomy and etymology[edit]

The generic name Diospyros comes from a Latin name for the Caucasian persimmon (D. lotus), derived from the Greek Diós (Διός) and pŷrós (πῦρός). The Greek name literally means "Zeus's wheat" but more generally intends "divine food" or "divine fruit".[2][3] Muddled translations sometimes give rise to curious and inappropriate interpretations such as "God's pear" and "Jove's fire".
The genus is a large one and the number of species has been estimated variously, depending on the date of the source. The Royal Botanic Gardens, Kew, list has over 1000 entries, including synonyms and items of low confidence. Over 700 species are marked as being assigned with high confidence.[4]

Chemotaxonomy[edit]

The leaves of Diospyros blancoi have been shown to contain isoarborinol methyl ether (also called cylindrin) and fatty esters of α- and β-amyrin.[5] Both isoarborinol methyl ether and the amyrin mixture demonstrated antimicrobial activity against Escherichia coliPseudomonas aeruginosaCandida albicansStaphylococcus aureus, and Trichophyton interdigitale.[5] Anti-inflammatory and analgesic properties have also been shown for the isolated amyrin mixture.[5]

Ecology[edit]

Diospyros species are important and conspicuous trees in many of their native ecosystems, such as lowland dry forests of the former Maui Nui in Hawaii,[6] Caspian Hyrcanian mixed forestsKathiarbar-Gir dry deciduous forestsLouisiade Archipelago rain forestsMadagascar lowland forestsNarmada Valley dry deciduous forestsNew Guinea mangroves or South Western Ghats montane rain forests. The green fruits are rich in tannins and thus avoided by most herbivores; when ripe they are eagerly eaten by many animals however, such as the rare Aders' duiker (Cephalophus adersi).
The foliage is used as food by the larvae of numerous Lepidoptera species:
An economically significant plant pathogen infecting many Diospyros species – D. hispidaKaki persimmon (D. kaki), Date-plum (D. lotus), Texas persimmon (D. texana), Coromandel ebony (D. melanoxylon) and probably others – is the sac fungusPseudocercospora kaki, which causes a leaf spot disease.
Ebony jivari of a sitar

Use by humans[edit]

Betulinic acid can be isolated from Diospyros leucomelas
The genus includes several plants of commercial importance, either for their edible fruit (persimmons) or for their timber (ebony). The latter are divided into two groups in trade: the pure black ebony (notably from D. ebenum, but also several other species), and the striped ebony or Calamander wood (from D. celebicaD. mun and others). Most species in the genus produce little to none of this black ebony-type wood; their hard timber (e.g. of American persimmonD. virginiana) may still be used on a more limited basis.
Leaves of the Coromandel ebony (D. melanoxylon) are used to roll South Asian beedi cigarettes. Several species are used in herbalism, and D. leucomelas yields the versatile medical compound betulinic acid. Extracts from Diospyros plants have also been proposed as novel anti-viral treatment.[7] Though bees do not play a key role as pollinators, in plantations Diospyros may be of some use as honey plantsD. mollis, locally known as mặc nưa, is used in Vietnam to dye the famous black lãnh Mỹ Asilk of Tân Châu district.
The reverence of these trees in their native range is reflected by their use as floral emblems. In IndonesiaD. celebica (Makassar ebony, known locally as Eboni) is the provincial tree of Central Sulawesi, while Ajan kelicung (D. macrophylla) is that of West Nusa Tenggara. The emblem of the Japanese island of Ishigaki is the Yaeyama kokutan (D. ferrea). The Gold apple (D. decandra), called "Trái thị" in Vietnamese, is a tree in the Tấm Cám fable. It is also the provincial tree of Chanthaburi as well as Nakhon Pathom Provinces in Thailand, while the Black-and-white ebony (D. malabarica) is that of Ang Thong Province. The name of the Thai district Amphoe Tha Tako, literally means "District of the Diospyros pier", the latter being a popular local gathering spot.

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