The theaflavin monomers inhibit the cancer cells growth in vitro

Theaflavin kháng Bel-7402

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Theaflavin

Names
IUPAC name 3,4,5-Trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-2-chromanyl]-6-benzo[7]annulenone
Identifiers
CAS Number	4670-05-7
3D model (JSmol)	Interactive image
ChemSpider	102754
PubChem CID	114777
UNII	1IA46M0D13
InChI[show]
SMILES[show]
Properties
Chemical formula	C29H24O12
Molar mass	564.50 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Theaflavin (TF) and its derivatives, known collectively as theaflavins, are antioxidant polyphenols that are formed from the condensation of flavan-3-ols in tea leaves during the enzymatic oxidation (sometimes erroneously referred to as fermentation) of black tea. Theaflavin-3-gallate, theaflavin-3'-gallate, theaflavin-3-3'-digallate are the main theaflavins.^[1]Theaflavins are types of thearubigins, and are therefore reddish in color. Epigallocatechin gallate (EGCG) will metabolize into some theaflavins in the liver.^{[citation needed]} Those molecules contain a tropolone moiety.

Contents

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• 1Research into health effects
  • 1.1HIV
  • 1.2Cholesterol
  • 1.3Cancer
• 2See also
• 3References

Research into health effects[edit]

HIV[edit]

In in vitro laboratory investigations, several tea polyphenols, especially those with galloyl moiety, can inhibit HIV-1 replication with multiple mechanisms of action. Theaflavin derivatives have been found to have more potent anti-HIV-1 activity than catechin derivatives.^[2]

Epigallocatechin gallate (EGCG), a catechin in green tea, binds to gp120, which works in conjunction with gp41, itself blocked by TF-3 (a theaflavin), both receptors of which HIV hijacks to enter into healthy human immune cells.^{[citation needed]}

Cholesterol[edit]

In a human clinical trial published in 2003, theaflavins were found to reduce blood cholesterol levels, both total and LDL.^[3]

Cancer[edit]

In in vitro laboratory investigations, theaflavins have been found to act on numerous points regulating cancer cell growth, survival, and metastasis.^[4] For example, TF-3 is a potent scavenger of superoxide.^[5]