Saturday, 10 June 2017

CLIC4 gen kháng Panc-1 (tế vào ung thư tụy)


CLIC4

From Wikipedia, the free encyclopedia
CLIC4
Protein CLIC4 PDB 2ahe.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLIC4, CLIC4L, H1, MTCLIC, huH1, p64H1, chloride intracellular channel 4
External IDsMGI: 1352754 HomoloGene: 8490 GeneCards:CLIC4
RNA expression pattern
PBB GE CLIC4 201559 s at fs.png

PBB GE CLIC4 221881 s at fs.png

PBB GE CLIC4 201560 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 1: 24.75 – 24.84 MbChr 4: 135.21 – 135.27 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse
Chloride intracellular channel 4, also known as CLIC4, is a eukaryotic gene.[3]
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits an intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).[3]

Binding partners[edit]

CLIC4 binds to dynamin I, α-tubulin, β-actincreatine kinase and two 14-3-3 isoforms.[4]

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