U937 (tế bào)

U937 cell-tế bào

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U937 cells are a model cell line used in biomedical research.^[1] They were isolated from the histiocytic lymphoma of a 37-year-old male patient ^[2] and are used to study the behaviour and differentiation of monocytes. U937 cells mature and differentiate in response to a number of soluble stimuli, adopting the morphology and characteristics of mature macrophages.

U937 cells are of the myeloid lineage and so secrete a large number of cytokines and chemokines either constitutively (e.g. IL-1 and GM-CSF) or in response to soluble stimuli. TNFα and recombinant GM-CSF independently promote IL-10 production in U937 cells.^[3]

The HLA alleles present in U937 cells are HLA-A*03:01, A*31:01, B*18:01, B*51:01, Cw*01:02 and Cw*07:02.^[4]